2. PI3K/Akt/mTOR
  3. mTOR
  4. NSC126405

NSC126405 is a mTOR-DEPTOR inhibitor that binds to DEPTOR, prevents mTOR-DEPTOR binding and induces multiple myeloma (MM) cytotoxicity. NSC126405 can be utilized in cancer research.

For research use only. We do not sell to patients.

NSC126405

NSC126405 Chemical Structure

CAS No. : 17581-52-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
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NSC126405 Related Antibodies

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  • Biological Activity

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Description

NSC126405 is a mTOR-DEPTOR inhibitor that binds to DEPTOR, prevents mTOR-DEPTOR binding and induces multiple myeloma (MM) cytotoxicity. NSC126405 can be utilized in cancer research[1].

Cellular Effect
Cell Line Type Value Description References
MM1.S IC50
3 μM
Compound: B; NSC126405
Cytotoxicity against human MM1S cells after 48 hrs by MTT assay
Cytotoxicity against human MM1S cells after 48 hrs by MTT assay
[PMID: 28916338]
PBL IC50
20 μM
Compound: B; NSC126405
Cytotoxicity against PBL (unknown origin) after 48 hrs by MTT assay
Cytotoxicity against PBL (unknown origin) after 48 hrs by MTT assay
[PMID: 28916338]
RPMI-8226 IC50
1.3 μM
Compound: B; NSC126405
Cytotoxicity against human RPMI8226 cells after 48 hrs by MTT assay
Cytotoxicity against human RPMI8226 cells after 48 hrs by MTT assay
[PMID: 28916338]
Molecular Weight

231.89

Formula

C5H2Cl4N2
CAS No.
Appearance

Solid

Color

Orange to red

SMILES

ClC(C(Cl)=C/1Cl)=C(Cl)C1=N\N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (431.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.3124 mL 21.5619 mL 43.1239 mL
5 mM 0.8625 mL 4.3124 mL 8.6248 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.3124 mL 21.5619 mL 43.1239 mL 107.8097 mL
5 mM 0.8625 mL 4.3124 mL 8.6248 mL 21.5619 mL
10 mM 0.4312 mL 2.1562 mL 4.3124 mL 10.7810 mL
15 mM 0.2875 mL 1.4375 mL 2.8749 mL 7.1873 mL
20 mM 0.2156 mL 1.0781 mL 2.1562 mL 5.3905 mL
25 mM 0.1725 mL 0.8625 mL 1.7250 mL 4.3124 mL
30 mM 0.1437 mL 0.7187 mL 1.4375 mL 3.5937 mL
40 mM 0.1078 mL 0.5390 mL 1.0781 mL 2.6952 mL
50 mM 0.0862 mL 0.4312 mL 0.8625 mL 2.1562 mL
60 mM 0.0719 mL 0.3594 mL 0.7187 mL 1.7968 mL
80 mM 0.0539 mL 0.2695 mL 0.5390 mL 1.3476 mL
100 mM 0.0431 mL 0.2156 mL 0.4312 mL 1.0781 mL
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NSC126405 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NSC12640517581-52-1NSC 126405NSC-126405mTORMammalian target of RapamycinmTOR-DEPTOR inhibitormultiple myelomacancerInhibitorinhibitorinhibit

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