Cat. No.: HY-12652

AZD3147

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

AZD3147 is a potent, orally active, selective dual inhibitor of mTORC1 and mTORC2 with an IC₅₀ value of 1.5 nM. AZD3147 also has a selective effect on PI3K.

For research use only. We do not sell to patients.

Purity: 99.93%
CAS No.: 1101810-02-9
Formula: C₂₄H₃₁N₅O₄S₂
Molecular Weight:517.66

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

AZD3147 Chemical Structure

CAS No.: 1101810-02-9

Size

Price

Stock

Quantity

Sample (0.1mg)

In-stock

(In Japan)

Apply Now

Get Quote Ask For Quote & Lead Time Consult sales personnel for more information Check price and availability Get Quote Ask For Quote & Lead Time Consult sales personnel for more information Check price and availability

Bulk Inquiry

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

AZD3147 is a potent, orally active, selective dual inhibitor of mTORC1 and mTORC2 with an IC₅₀ value of 1.5 nM. AZD3147 also has a selective effect on PI3K^[1].

IC₅₀ & Target^[1]

mTORC1

mTORC2

All mTOR Isoforms :

In Vitro

AZD3147 (0-50 nM, 1 h) can alleviate fibroblast growth factor (FGF)-mediated cilia extension at concentrations above 1.5 nM in NIH3T3 cells^[2].
AZD3147 inhibits cell viability of neuroblastoma cell lines Kelly and IMR-32 with the IC₅₀ values of 0.88 nM and 662.4 nM, respectively^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The pharmacokinetic parameters of AZD3147^[1].

Parameter	Mouse	Dog
CL (mL/min/kg)	78	16
Vss (L/kg)	2.3	2.2
t_1/2(h)	0.9	1.9
F%	61	73

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1101810-02-9
Appearance Solid
Molecular Weight 517.66
Formula C₂₄H₃₁N₅O₄S₂
Color Off-white to light yellow
SMILES

O=S(C1(C2=NC(C3=CC=C(C=C3)NC(NCCO)=S)=NC(N4[C@H](COCC4)C)=C2)CC1)(C5CC5)=O
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

All

Sort by:

Journal Impact Factor

Comput Methods Biomech Biomed Engin

Harnessing glycolysis- and cholesterol synthesis-related genes for prognostic modeling in lung adenocarcinoma. [Abstract]

2025 Sep 17:1-19. PMID: 40959888

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (241.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.9318 mL

9.6588 mL

19.3177 mL

5 mM

0.3864 mL

1.9318 mL

3.8635 mL

10 mM

0.1932 mL

0.9659 mL

1.9318 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kurt G Pike, et al. Discovery of AZD3147: a potent, selective dual inhibitor of mTORC1 and mTORC2. J Med Chem. 2015 Mar 12;58(5):2326-49.

[2]. Michaela Kunova Bosakova, et al. Regulation of ciliary function by fibroblast growth factor signaling identifies FGFR3-related disorders achondroplasia and thanatophoric dysplasia as ciliopathies. Hum Mol Genet. 2018 Mar 15;27(6):1093-1105. [Content Brief]

[3]. Rebecca Waetzig, et al. Comparing mTOR inhibitor Rapamycin with Torin-2 within the RIST molecular-targeted regimen in neuroblastoma cells. Int J Med Sci. 2021 Jan 1;18(1):137-149. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.9318 mL	9.6588 mL	19.3177 mL	48.2942 mL
	5 mM	0.3864 mL	1.9318 mL	3.8635 mL	9.6588 mL
	10 mM	0.1932 mL	0.9659 mL	1.9318 mL	4.8294 mL
	15 mM	0.1288 mL	0.6439 mL	1.2878 mL	3.2196 mL
	20 mM	0.0966 mL	0.4829 mL	0.9659 mL	2.4147 mL
	25 mM	0.0773 mL	0.3864 mL	0.7727 mL	1.9318 mL
	30 mM	0.0644 mL	0.3220 mL	0.6439 mL	1.6098 mL
	40 mM	0.0483 mL	0.2415 mL	0.4829 mL	1.2074 mL
	50 mM	0.0386 mL	0.1932 mL	0.3864 mL	0.9659 mL
	60 mM	0.0322 mL	0.1610 mL	0.3220 mL	0.8049 mL
	80 mM	0.0241 mL	0.1207 mL	0.2415 mL	0.6037 mL
	100 mM	0.0193 mL	0.0966 mL	0.1932 mL	0.4829 mL

Keywords

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

AZD3147

Kinase Inhibitor Library

PI3K/Akt/mTOR Compound Library

Stem Cell Signaling Compound Library

Anti-Cancer Compound Library

Autophagy Compound Library

Anti-Aging Compound Library

Antioxidant Compound Library

Differentiation Inducing Compound Library

Reprogramming Compound Library

Oxygen Sensing Compound Library

Glycolysis Compound Library

Cytoskeleton Compound Library

Orally Active Compound Library

Glutamine Metabolism Compound Library

Anti-Breast Cancer Compound Library

Anti-Lung Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Anti-Cancer Metabolism Compound Library

Anti-Obesity Compound Library

Angiogenesis-Related Compound Library

Lipid Metabolism Compound Library

Glucose Metabolism Compound Library

Anti-Liver Cancer Compound Library

Anti-Colorectal Cancer Compound Library

Anti-Prostate Cancer Compound Library

Anti-Pulmonary Fibrosis Compound Library

Cancer Stem Cells Compound Library

Heterocyclic Compound Library

Pain-Related Compound Library

Mitochondrial Protection Compound Library

Highly Selective Inhibitors Library

Serine/Threonine Kinase Inhibitor Library

Anti-Hematopathy Compound Library

Anti-Ovarian Cancer Compound Library

Multi-Target Compound Library

Radioprotector Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Anti-Gastric Cancer Compound Library

Anti-Fibrosis Compound Library

Anti-Brain Cancer Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

Lactylation Compound Library

Publications Citing Use of MedChemExpress (MCE) AZD3147

All mTOR Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

AZD3147 Related Classifications

Cat. No.: HY-12652