2. PI3K/Akt/mTOR
  3. mTOR
  4. AZD3147

AZD3147 is a potent, orally active, selective dual inhibitor of mTORC1 and mTORC2 with an IC50 value of 1.5 nM. AZD3147 also has a selective effect on PI3K.

For research use only. We do not sell to patients.

AZD3147 Chemical Structure

AZD3147 Chemical Structure

CAS No. : 1101810-02-9

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1 mg USD 211 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

AZD3147 Related Antibodies

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mTOR mTORC1 mTORC2

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

AZD3147 is a potent, orally active, selective dual inhibitor of mTORC1 and mTORC2 with an IC50 value of 1.5 nM. AZD3147 also has a selective effect on PI3K[1].
IC50 & Target[1]

mTORC1

 

mTORC2

 

In Vitro

AZD3147 (0-50 nM, 1 h) can alleviate fibroblast growth factor (FGF)-mediated cilia extension at concentrations above 1.5 nM in NIH3T3 cells[2].
AZD3147 inhibits cell viability of neuroblastoma cell lines Kelly and IMR-32 with the IC50 values of 0.88 nM and 662.4 nM, respectively[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AZD3147 Related Antibodies
In Vivo

The pharmacokinetic parameters of AZD3147[1].

Parameter Mouse Dog
CL (mL/min/kg) 78 16
Vss (L/kg) 2.3 2.2
t1/2(h) 0.9 1.9
F% 61 73

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

517.66

Formula

C24H31N5O4S2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=S(C1(C2=NC(C3=CC=C(C=C3)NC(NCCO)=S)=NC(N4[C@H](COCC4)C)=C2)CC1)(C5CC5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (241.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9318 mL 9.6588 mL 19.3177 mL
5 mM 0.3864 mL 1.9318 mL 3.8635 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9318 mL 9.6588 mL 19.3177 mL 48.2942 mL
5 mM 0.3864 mL 1.9318 mL 3.8635 mL 9.6588 mL
10 mM 0.1932 mL 0.9659 mL 1.9318 mL 4.8294 mL
15 mM 0.1288 mL 0.6439 mL 1.2878 mL 3.2196 mL
20 mM 0.0966 mL 0.4829 mL 0.9659 mL 2.4147 mL
25 mM 0.0773 mL 0.3864 mL 0.7727 mL 1.9318 mL
30 mM 0.0644 mL 0.3220 mL 0.6439 mL 1.6098 mL
40 mM 0.0483 mL 0.2415 mL 0.4829 mL 1.2074 mL
50 mM 0.0386 mL 0.1932 mL 0.3864 mL 0.9659 mL
60 mM 0.0322 mL 0.1610 mL 0.3220 mL 0.8049 mL
80 mM 0.0241 mL 0.1207 mL 0.2415 mL 0.6037 mL
100 mM 0.0193 mL 0.0966 mL 0.1932 mL 0.4829 mL
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AZD3147 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AZD31471101810-02-9AZD 3147AZD-3147mTORMammalian target of RapamycinmTORC1/2 inhibitorrapamycin complexmTORC1mTORC2dual inhibitorInhibitorinhibitorinhibit

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