製品番号: HY-12652

AZD3147

1 Cited Publications

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

AZD3147 is a potent, orally active, selective dual inhibitor of mTORC1 and mTORC2 with an IC₅₀ value of 1.5 nM. AZD3147 also has a selective effect on PI3K.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 99.93%
CAS 番号: 1101810-02-9
分子式: C₂₄H₃₁N₅O₄S₂
分子量:517.66

保管条件:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

AZD3147 構造式

CAS 番号: 1101810-02-9

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
Publications (1)
溶剤 & 溶解度
- 体外
純度とドキュメンテーション
参考文献
Help & FAQs
関連分類
Bioz

生物活性

製品説明

AZD3147 is a potent, orally active, selective dual inhibitor of mTORC1 and mTORC2 with an IC₅₀ value of 1.5 nM. AZD3147 also has a selective effect on PI3K^[1].

IC₅₀ & Target^[1]

mTORC1

mTORC2

mTOR アイソフォーム固有の製品をすべて表示 :

体外実験

AZD3147 (0-50 nM, 1 h) can alleviate fibroblast growth factor (FGF)-mediated cilia extension at concentrations above 1.5 nM in NIH3T3 cells^[2].
AZD3147 inhibits cell viability of neuroblastoma cell lines Kelly and IMR-32 with the IC₅₀ values of 0.88 nM and 662.4 nM, respectively^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

The pharmacokinetic parameters of AZD3147^[1].

Parameter	Mouse	Dog
CL (mL/min/kg)	78	16
Vss (L/kg)	2.3	2.2
t_1/2(h)	0.9	1.9
F%	61	73

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 1101810-02-9
性状 Solid
分子量 517.66
分子式 C₂₄H₃₁N₅O₄S₂
Color Off-white to light yellow
SMILES

O=S(C1(C2=NC(C3=CC=C(C=C3)NC(NCCO)=S)=NC(N4[C@H](COCC4)C)=C2)CC1)(C5CC5)=O
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Comput Methods Biomech Biomed Engin

Harnessing glycolysis- and cholesterol synthesis-related genes for prognostic modeling in lung adenocarcinoma. [Abstract]

2025 Sep 17:1-19. PMID: 40959888

溶剤 & 溶解度

体外:

DMSO : 125 mg/mL (241.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.9318 mL

9.6588 mL

19.3177 mL

5 mM

0.3864 mL

1.9318 mL

3.8635 mL

10 mM

0.1932 mL

0.9659 mL

1.9318 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (274 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Kurt G Pike, et al. Discovery of AZD3147: a potent, selective dual inhibitor of mTORC1 and mTORC2. J Med Chem. 2015 Mar 12;58(5):2326-49.

[2]. Michaela Kunova Bosakova, et al. Regulation of ciliary function by fibroblast growth factor signaling identifies FGFR3-related disorders achondroplasia and thanatophoric dysplasia as ciliopathies. Hum Mol Genet. 2018 Mar 15;27(6):1093-1105. [Content Brief]

[3]. Rebecca Waetzig, et al. Comparing mTOR inhibitor Rapamycin with Torin-2 within the RIST molecular-targeted regimen in neuroblastoma cells. Int J Med Sci. 2021 Jan 1;18(1):137-149. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.9318 mL	9.6588 mL	19.3177 mL	48.2942 mL
	5 mM	0.3864 mL	1.9318 mL	3.8635 mL	9.6588 mL
	10 mM	0.1932 mL	0.9659 mL	1.9318 mL	4.8294 mL
	15 mM	0.1288 mL	0.6439 mL	1.2878 mL	3.2196 mL
	20 mM	0.0966 mL	0.4829 mL	0.9659 mL	2.4147 mL
	25 mM	0.0773 mL	0.3864 mL	0.7727 mL	1.9318 mL
	30 mM	0.0644 mL	0.3220 mL	0.6439 mL	1.6098 mL
	40 mM	0.0483 mL	0.2415 mL	0.4829 mL	1.2074 mL
	50 mM	0.0386 mL	0.1932 mL	0.3864 mL	0.9659 mL
	60 mM	0.0322 mL	0.1610 mL	0.3220 mL	0.8049 mL
	80 mM	0.0241 mL	0.1207 mL	0.2415 mL	0.6037 mL
	100 mM	0.0193 mL	0.0966 mL	0.1932 mL	0.4829 mL

Keywords

AZD3147

1 Cited Publications

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AZD3147

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Anti-Aging Compound Library

MedChemExpress（MCE）の使用を引用している文献 AZD3147

mTOR アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (1)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

AZD3147 関連分類

HY-12652 関連分類