1. PI3K/Akt/mTOR
  2. PI3K mTOR
  3. PI3K-IN-22

PI3K-IN-22 is a PI3Kα/mTOR dual kinase inhibitor. PI3K-IN-22 has IC50s of 0.9, 0.6 nM for PI3Kα and mTOR, respectively. PI3K-IN-22 can be used for the research of cancer.

For research use only. We do not sell to patients.

PI3K-IN-22 Chemical Structure

PI3K-IN-22 Chemical Structure

CAS No. : 1202884-94-3

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Based on 1 publication(s) in Google Scholar

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Description

PI3K-IN-22 is a PI3Kα/mTOR dual kinase inhibitor. PI3K-IN-22 has IC50s of 0.9, 0.6 nM for PI3Kα and mTOR, respectively. PI3K-IN-22 can be used for the research of cancer[1].

IC50 & Target[1]

PI3Kα

0.9 nM (IC50)

mTOR

0.6 nM (IC50)

In Vitro

PI3K-IN-22 (compound 46) inhibits the cell growth of PC3 and MDA-361 cells with IC50s of <3.0 and 13.0 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PI3K-IN-22 (25 mg/kg; i.v.) suppresses phosphorylation of Akt T308, Akt S473 and S6K in MDA361 breast tumor cells up to 8 h in MDA361 tumor bearing nude mice demonstrated by biomarker studies[1].
PI3K-IN-22 (50, 25, 10 mg/kg; i.v.; once daily for 5 days weekly; 2 rounds) shows good antitumor efficacy in MDA361 tumor xenograft nude mice model[1].
PI3K-IN-22 (25 mg/kg; i.v.; a single dose) has a blood concentrationsat value of 1731 ng/mL at 8 h[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MDA361 tumor xenograft nude mice model[1]
Dosage: 50, 25, 10 mg/kg
Administration: i.v., once daily for 5 days weekly (2 rounds)
Result: Exhibited significant tumor regression in 50 mg/kg and no tumor regrowth until day 32.
Exhibited tumor growth inhibition in 25 and 10 mg/kg.
Molecular Weight

624.66

Formula

C31H35F3N8O3

CAS No.
SMILES

O=C(NC1=CC=C(C(N(C)CCN(C)C)=O)C=C1)NC(C=C2)=CC=C2C3=NC4=C(C=CN4CC(F)(F)F)C(N5CCOCC5)=N3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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PI3K-IN-22 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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PI3K-IN-22
Cat. No.:
HY-10620
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