PI3K-IN-22
Based on 1 Customer Validation
PI3K-IN-22 is a PI3Kα/mTOR dual kinase inhibitor. PI3K-IN-22 has IC50s of 0.9, 0.6 nM for PI3Kα and mTOR, respectively. PI3K-IN-22 can be used for the research of cancer.
For research use only. We do not sell to patients.
- Purity: 99.50%
- CAS No.: 1202884-94-3
- Formula: C31H35F3N8O3
- Molecular Weight:624.66
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PI3Kα 0.9 nM (IC50) |
mTOR 0.6 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDA-MB-361 | IC50 |
<3 nM
Compound: 46
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Cytotoxicity against human MDA-MB-361 cells with Her2+/PI3KCA mutant after 72 hrs
Cytotoxicity against human MDA-MB-361 cells with Her2+/PI3KCA mutant after 72 hrs
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[PMID: 20334367] |
| PC-3 | IC50 |
13 nM
Compound: 46
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Cytotoxicity against human PC3 cells with PTEN mutant after 72 hrs
Cytotoxicity against human PC3 cells with PTEN mutant after 72 hrs
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[PMID: 20334367] |
PI3K-IN-22 (compound 46) inhibits the cell growth of PC3 and MDA-361 cells with IC50s of <3.0 and 13.0 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
PI3K-IN-22 (50, 25, 10 mg/kg; i.v.; once daily for 5 days weekly; 2 rounds) shows good antitumor efficacy in MDA361 tumor xenograft nude mice model[1].
PI3K-IN-22 (25 mg/kg; i.v.; a single dose) has a blood concentrationsat value of 1731 ng/mL at 8 h[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:MDA361 tumor xenograft nude mice model[1]
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Dosage:50, 25, 10 mg/kg
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Administration:i.v., once daily for 5 days weekly (2 rounds)
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Result:Exhibited significant tumor regression in 50 mg/kg and no tumor regrowth until day 32.
Exhibited tumor growth inhibition in 25 and 10 mg/kg.
Chemical Information
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CAS No. 1202884-94-3
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Appearance Solid
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Molecular Weight 624.66
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Formula C31H35F3N8O3
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Color White to light yellow
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SMILES
O=C(NC1=CC=C(C(N(C)CCN(C)C)=O)C=C1)NC(C=C2)=CC=C2C3=NC4=C(C=CN4CC(F)(F)F)C(N5CCOCC5)=N3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 15 mg/mL (24.01 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6009 mL | 8.0044 mL | 16.0087 mL | 40.0218 mL |
| 5 mM | 0.3202 mL | 1.6009 mL | 3.2017 mL | 8.0044 mL | |
| 10 mM | 0.1601 mL | 0.8004 mL | 1.6009 mL | 4.0022 mL | |
| 15 mM | 0.1067 mL | 0.5336 mL | 1.0672 mL | 2.6681 mL | |
| 20 mM | 0.0800 mL | 0.4002 mL | 0.8004 mL | 2.0011 mL |
PI3K-IN-22 Related Classifications
HY-10620 Related Classifications
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