1. PI3K/Akt/mTOR
  2. PI3K
    mTOR
  3. PI3K-IN-22

PI3K-IN-22 

Cat. No.: HY-10620
Handling Instructions

PI3K-IN-22 is a PI3Kα/mTOR dual kinase inhibitor. PI3K-IN-22 has IC50s of 0.9, 0.6 nM for PI3Kα and mTOR, respectively. PI3K-IN-22 can be used for the research of cancer.

For research use only. We do not sell to patients.

PI3K-IN-22 Chemical Structure

PI3K-IN-22 Chemical Structure

CAS No. : 1202884-94-3

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Description

PI3K-IN-22 is a PI3Kα/mTOR dual kinase inhibitor. PI3K-IN-22 has IC50s of 0.9, 0.6 nM for PI3Kα and mTOR, respectively. PI3K-IN-22 can be used for the research of cancer[1].

IC50 & Target[1]

PI3Kα

0.9 nM (IC50)

mTOR

0.6 nM (IC50)

In Vitro

PI3K-IN-22 (compound 46) inhibits the cell growth of PC3 and MDA-361 cells with IC50s of <3.0 and 13.0 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PI3K-IN-22 (25 mg/kg; i.v.) suppresses phosphorylation of Akt T308, Akt S473 and S6K in MDA361 breast tumor cells up to 8 h in nude mouse[1].
PI3K-IN-22 (50, 25, 10 mg/kg; i.v.; once daily for 5 days weekly; 2 rounds) exhibits significant tumor regression in 50 mg/kg and no tumor regrowth until day 32, and tumor growth inhibition in 25 and 10 mg/kg in MDA361 tumor xenograft nude mice model[1].
PI3K-IN-22 (25 mg/kg; i.v.; a single dose) has a blood concentrationsat value of 1731 ng/mL at 8 h[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

624.66

Formula

C₃₁H₃₅F₃N₈O₃

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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PI3K-IN-22
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