1. PROTAC
    Metabolic Enzyme/Protease
  2. PROTACs
    Phosphatase
  3. SHP2-D26

SHP2-D26 

Cat. No.: HY-145162
Handling Instructions

SHP2-D26 is a first, potent and effective SHP2 degrader. SHP2-D26 induces SHP2 degradation requires binding to VHL-1 and SHP2 proteins. SHP2-D26 is also neddylation- and proteasome-dependent.

For research use only. We do not sell to patients.

SHP2-D26 Chemical Structure

SHP2-D26 Chemical Structure

CAS No. : 2458219-65-1

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Description

SHP2-D26 is a first, potent and effective SHP2 degrader. SHP2-D26 induces SHP2 degradation requires binding to VHL-1 and SHP2 proteins. SHP2-D26 is also neddylation- and proteasome-dependent[1].

IC50 & Target

SHP2[1]

In Vitro

SHP2-D26 (0, 3, 10, 30, 100, 300 nM; 12 hours) effectively reduces SHP2 protein in a dosedependent manner, with DC50 values of 6.0 nM, 2.6 nM in KYSE520 and MV-4-11 cells, respectively[1].
SHP2-D26 (100 nM; 0, 2, 4, 8, 12, 24 hours) reduces the SHP2 protein level within 4 h and completes SHP2 depletion with 8 h in KYSE520 and MV-4-11 cells[1].
SHP2-D26 (0-100 μM for KYSE520 cells; 0-10 nM for MV-4-11 cells; 4 days) achieves IC50 values of 0.66 μM, 0.99 nM in KYSE520 and MV-4-11 cells, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: KYSE520 and MV-4-11 cells
Concentration: 0-100 μM for KYSE520 cells; 0-10 nM for MV-4-11 cells
Incubation Time: 4 days
Result: Achieved IC50 values of 0.66 μM, 0.99 nM in KYSE520 and MV-4-11 cells, respectively.

Western Blot Analysis[1]

Cell Line: KYSE520 and MV-4-11 cells
Concentration: 0, 3, 10, 30, 100, 300 nM
Incubation Time: 12 hours
Result: Reduced SHP2 protein in a dosedependent manner, with DC50 values of 6.0 and 2.6 nM in KYSE520 and MV-4-11 cells, respectively.

Western Blot Analysis[1]

Cell Line: KYSE520 and MV-4-11 cells
Concentration: 100 nM
Incubation Time: 0, 2, 4, 8, 12, 24 hours
Result: Reduced the SHP2 protein level within 4 h and completed SHP2 depletion with 8 h.
Molecular Weight

1115.89

Formula

C₅₆H₇₉ClN₁₂O₆S₂

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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SHP2-D26
Cat. No.:
HY-145162
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