KB02
KB02 is a DCAF16-recruiting ligand that covalently binds to a ligandable cysteine on DCAF16, recruiting the E3 ligase to mediate target protein degradation. KB02 serves as a DCAF16-binding fragment for the synthesis of SHP2 PROTACs.
For research use only. We do not sell to patients.
- CAS No.: 62265-73-0
- Formula: C11H12ClNO2
- Molecular Weight:225.67
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
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DCAF16 |
In Vitro
KB02 (7.5 μM; 24 h) alone does not induce SHP2 degradation in HeLa cells but competes with SK8 for DCAF16 binding, thereby inhibiting SK8-induced SHP2 degradation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa
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Concentration:7.5 μM
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Incubation Time:24 h
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Result:Lacked the capability to induce SHP2 degradation.
Significantly inhibited SK8-induced SHP2 degradation.\nDid not induce SHP2 degradation.
Significantly inhibited SK8-induced SHP2 degradation.
Chemical Information
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CAS No. 62265-73-0
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Molecular Weight 225.67
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Formula C11H12ClNO2
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SMILES
OC1=CC=C(N(C(CCl)=O)CCC2)C2=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KB02 Related Classifications
HY-189472 Related Classifications
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