1. PI3K/Akt/mTOR
    Epigenetics
    Cell Cycle/DNA Damage
  2. mTOR
    HDAC
  3. mTOR/HDAC-IN-1

mTOR/HDAC-IN-1 

Cat. No.: HY-141701
Handling Instructions

mTOR/HDAC-IN-1 (Compound 50) is a selective mTOR and HDAC dual inhibitor with IC50 values of 0.49 and 0.91 nM against mTOR and HDAC1, respectively. mTOR/HDAC-IN-1 can be studied as an anti-cancer agent.

For research use only. We do not sell to patients.

mTOR/HDAC-IN-1 Chemical Structure

mTOR/HDAC-IN-1 Chemical Structure

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Description

mTOR/HDAC-IN-1 (Compound 50) is a selective mTOR and HDAC dual inhibitor with IC50 values of 0.49 and 0.91 nM against mTOR and HDAC1, respectively. mTOR/HDAC-IN-1 can be studied as an anti-cancer agent[1].

IC50 & Target

mTOR

0.49 nM (IC50)

HDAC1

0.91 nM (IC50)

HDAC6

86 nM (IC50)

HDAC8

27 nM (IC50)

In Vitro

mTOR/HDAC-IN-1 (Compound 50) (0-10 μM, 72 h) shows remarkable anti-proliferative activity against A549, HCT116, and MV4-11 cells[1].
mTOR/HDAC-IN-1 (0-3 μM, 6 h) simultaneous modulates mTOR signaling and HDAC catalytic activity at cellular level[1].
mTOR/HDAC-IN-1 displays excellent specificity over both HDAC6 and HDAC11 (with IC50 values of 0.91, 86, 27, and >1000 against HDAC1, HDAC6, HDAC8 and HDAC11) [1].
mTOR/HDAC-IN-1 maintains the interaction of MLN0128 with the ATP-binding site in mTOR and binds with the catalytic channel in HDAC[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: A549, HCT116, and MV4-11
Concentration: 0-10 μM
Incubation Time: At 70 h post-compound treatment, to each well was added CCK-8, and the mixture was incubated for additional 2 h.
Result: Showed anti-proliferative activity with IC50 values of 2.16, 3.85, and 1.74 μM against A549, HCT116, and MV4-11 cells, respectively.

Western Blot Analysis[1]

Cell Line: MV4-11
Concentration: 0.3, 1.0, and 3.0 μM
Incubation Time: 6 h
Result: Downregulated the levels of Phos-S6 (Ser235/Ser236) and Phos-AKT (Ser473), and elevated the levels of Ac-H3 (K9) and Acα-tubulin (Lys40) in a concentration-dependent manner.
Molecular Weight

501.50

Formula

C23H23N11O3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Product Name:
mTOR/HDAC-IN-1
Cat. No.:
HY-141701
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