CAII-IN-12
CAII-IN-12 (compound 6c) is a potent and selective carbonic anhydrase (CA) II and VII inhibitor (hCA II Ki = 47.8 nM, hCA VII Ki = 3.6 nM) with anti-epilepitic activity. CAII-IN-12 displays selectivity over hCA I (Ki = 370 nM). CAII-IN-12 exhibits potent anticonvulsant activity in both Pentylenetetrazol- and Pilocarpine (HY-B0726A)-induced seizure mouse models. CAII-IN-12 increases expression of KCC2 in the hippocampus, maintains neuronal integrity, and reduces mTOR activity. CAII-IN-12 can be used for epilepsy research.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C19H16N4O7S2
- Molecular Weight:476.48
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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hCA II 47.8 nM (Ki) |
hCA VII 3.6 nM (Ki) |
hCA I 370 nM (Ki) |
Chemical Information
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Molecular Weight 476.48
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Formel C19H16N4O7S2
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SMILES
O=C(NC1=CC=C(S(=O)(N)=O)C=C1)CCN(C/2=O)C(SC2=C/C3=CC=C([N+]([O-])=O)C=C3)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
CAII-IN-12 Related Classifications
HY-180056 Related Classifications
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