(S)-2-Amino-5,5,5-trifluoropentanoic acid (Synonyms: (S)-5,5,5-Trifluoronorvaline; H-Nva(5,5,5-triF)-OH)

Cat. No.: HY-W074912: Data Sheet Handling Instructions
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(S)-2-Amino-5,5,5-trifluoropentanoic acid ((S)-5,5,5-Trifluoronorvaline; H-Nva (5,5,5-triF)-OH) is a selective Sestrin-GATOR2 modulator that indirectly inhibits mTORC1 activity via a competitive binding mechanism. (S)-2-Amino-5,5,5-trifluoropentanoic acid can be used in research on cancer, metabolic diseases, neurodegenerative diseases, and muscle atrophy.\n

For research use only. We do not sell to patients.

(S)-2-Amino-5,5,5-trifluoropentanoic acid Chemical Structure

CAS No. : 122565-28-0

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50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
250 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
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Description

IC₅₀ & Target^[1]

mTORC1

In Vitro

(S)-2-Amino-5,5,5-trifluoropentanoic acid (I-6) shows no significant modulation of Sestrin2-GATOR2 binding, with activity relative to leucine falling between -40% and 40%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

171.12

Formula

C₅H₈F₃NO₂

CAS No.

122565-28-0

SMILES

C([C@@H](C(O)=O)N)CC(F)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Fetalvero K M, et al. Imaging device, electronic equipment, and imaging method. WO2017070518A1. WIPO. 2017-04-27.

(S)-2-Amino-5,5,5-trifluoropentanoic acid Related Classifications

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The molarity calculator equation

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-2-Amino-5,5,5-trifluoropentanoic acid122565-28-0(S)-5,5,5-Trifluoronorvaline H-Nva(5,5,5-triF)-OHmTORMammalian target of RapamycinSestrin2-GATOR2 binding assaySestrin2-GATOR2Sestrin-GATOR2leucineInhibitorinhibitorinhibit

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