(S)-2-Amino-5,5,5-trifluoropentanoic acid
Based on 1 Customer Validation
(S)-2-Amino-5,5,5-trifluoropentanoic acid ((S)-5,5,5-Trifluoronorvaline; H-Nva (5,5,5-triF)-OH) is a selective Sestrin-GATOR2 modulator that indirectly inhibits mTORC1 activity via a competitive binding mechanism. (S)-2-Amino-5,5,5-trifluoropentanoic acid can be used in research on cancer, metabolic diseases, neurodegenerative diseases, and muscle atrophy.\n
For research use only. We do not sell to patients.
- CAS No.: 122565-28-0
- Formula: C5H8F3NO2
- Molecular Weight:171.12
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
mTORC1 |
In Vitro
(S)-2-Amino-5,5,5-trifluoropentanoic acid (I-6) shows no significant modulation of Sestrin2-GATOR2 binding, with activity relative to leucine falling between -40% and 40%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 122565-28-0
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Appearance Solid
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Molecular Weight 171.12
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Formula C5H8F3NO2
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Color White to off-white
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SMILES
C([C@@H](C(O)=O)N)CC(F)(F)F
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Synonyms
(S)-5,5,5-Trifluoronorvaline; H-Nva(5,5,5-triF)-OH
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(S)-2-Amino-5,5,5-trifluoropentanoic acid Related Classifications
HY-W074912 Related Classifications
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