1. PI3K/Akt/mTOR
  2. mTOR
  3. Rheb inhibitor NR1

Rheb inhibitor NR1 

Cat. No.: HY-124798 Purity: >98.0%
Handling Instructions

Rheb inhibitor NR1 is a Rheb inhibitor with an IC50 of 2.1 µM in the Rheb-IVK assay. Rheb inhibitor NR1 also is a selective mTORC1 inhibitor. NR1 inhibits the phosphorylation of T389pS6K1 and increases the phosphorylation of S473pAKT in a dose-dependent manner.

For research use only. We do not sell to patients.

Rheb inhibitor NR1 Chemical Structure

Rheb inhibitor NR1 Chemical Structure

CAS No. : 2216763-38-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 636 In-stock
Estimated Time of Arrival: December 31
5 mg USD 500 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

* Please select Quantity before adding items.

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Based on 1 publication(s) in Google Scholar

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Description

Rheb inhibitor NR1 is a Rheb inhibitor with an IC50 of 2.1 µM in the Rheb-IVK assay. Rheb inhibitor NR1 also is a selective mTORC1 inhibitor. NR1 inhibits the phosphorylation of T389pS6K1 and increases the phosphorylation of S473pAKT in a dose-dependent manner[1].

Molecular Weight

578.30

Formula

C₂₅H₁₉BrCl₂N₂O₃S

CAS No.

2216763-38-9

SMILES

O=C(C(N1CC2=CC=C(C(N(C)C)=O)C=C2)=CC3=C1C=C(SC4=CC=C(Cl)C(Cl)=C4)C=C3Br)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (172.92 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7292 mL 8.6460 mL 17.2921 mL
5 mM 0.3458 mL 1.7292 mL 3.4584 mL
10 mM 0.1729 mL 0.8646 mL 1.7292 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.32 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: >98.0%

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Keywords:

Rheb inhibitor NR1Rheb inhibitor NR 1Rheb inhibitor NR-1mTORMammalian target of RapamycinInhibitorinhibitorinhibit

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Product Name:
Rheb inhibitor NR1
Cat. No.:
HY-124798
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