Topo I/II-IN-2
Topo I/II-IN-2 (Compound 3g) is an inhibitor of Topo I and Topo II. Topo I/II-IN-2 inhibits NCI-H446 cells and NCI-H1048 cells with IC50s of 1.30 μM and 1.42 μM, respectively. Topo I/II-IN-2 induces mitochondrial Apoptosis, mitochondrial dysfunction and activity generation. Topo I/II-IN-2 inhibits the PI3K/Akt/mTOR pathway. Topo I/II-IN-2 prevents SCLC (small cell lung cancer) cell proliferation, invasion, and migration in vitro. .
For research use only. We do not sell to patients.
- Formula: C25H26N2O4
- Molecular Weight:418.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Topoisomerase I |
Topoisomerase II |
Bcl-2 |
Bax |
Caspase 3 |
Caspase 9 |
Chemical Information
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Molecular Weight 418.48
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Formula C25H26N2O4
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SMILES
CC(C1)CC(C)CN1CC2=CC(OCO3)=C3C=C2C4=CC(C=CC5=C6OCO5)=C6C=N4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Topo I/II-IN-2 Related Classifications
HY-170912 Related Classifications
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