2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling TGF-beta/Smad
  3. JAK TGF-β Receptor
  4. Itacnosertib (hydrocholide)

Itacnosertib (hydrocholide)  (Synonyms: TP-0184 (hydrocholide))

Cat. No.: HY-109179A Purity: 98.98%
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Itacnosertib hydrocholide is an inhibitor of JAK2, ACVR1 (ALK2) and ALK5.

For research use only. We do not sell to patients.

Itacnosertib (hydrocholide) Chemical Structure

Itacnosertib (hydrocholide) Chemical Structure

CAS No. : 2409543-84-4

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5 mg USD 260 In-stock
10 mg USD 420 In-stock
25 mg USD 800 In-stock
50 mg USD 1280 In-stock
100 mg USD 1950 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Itacnosertib (hydrocholide):

Itacnosertib (hydrocholide) Related Antibodies

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Description

Itacnosertib hydrocholide is an inhibitor of JAK2, ACVR1 (ALK2) and ALK5[1].

Molecular Weight

505.01

Formula

C26H29ClN8O
CAS No.
Appearance

Solid

Color

Off-white to light brown

SMILES

CN1CCN(C2=CC=C(NC3=NC=CC(NC4=CC=CN=C4C5=NC=CC=C5)=N3)C=C2OC)CC1.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 5.56 mg/mL (11.01 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9802 mL 9.9008 mL 19.8016 mL
5 mM 0.3960 mL 1.9802 mL 3.9603 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9802 mL 9.9008 mL 19.8016 mL 49.5040 mL
5 mM 0.3960 mL 1.9802 mL 3.9603 mL 9.9008 mL
10 mM 0.1980 mL 0.9901 mL 1.9802 mL 4.9504 mL
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Itacnosertib (hydrocholide) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Itacnosertib (hydrocholide)2409543-84-4TP-0184 (hydrocholide)JAKTGF-β ReceptorJanus kinaseTransforming growth factor beta receptorsJAK2/ACVR1 (ALK2)/ALK5 inhibitorCancerInhibitorinhibitorinhibit

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