PI3K/mTOR-IN-23 dihydrochloride 

PI3K/mTOR-IN-23 dihydrochloride is a dual inhibitor of PI3K and mTOR with IC₅₀ values of 49 and 41 nM. PI3K/mTOR-IN-23 dihydrochloride inhibits cancer cells proliferation^[1].

PI3K/mTOR-IN-23 (Compound 1) dihydrochloride acts as a dual inhibitor of mTOR and PI3K-α in recombinant enzyme assays, with an mTOR IC₅₀ of 49 nM, a PI3K-α IC₅₀ of 41 nM^[1].
PI3K/mTOR-IN-23 dihydrochloride inhibits LNCaP cell proliferation with an IC₅₀ of 1300 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

386.30

C₁₆H₁₇Cl₂N₃O₂S

1188890-32-5

Solid

White to off-white

OC1=CC(C2=NC(N3CCOCC3)=C4SC=CC4=N2)=CC=C1.Cl.Cl

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Verheijen J C, et al. Discovery of 2-arylthieno [3, 2-d] pyrimidines containing 8-oxa-3-azabi-cyclo [3.2. 1] octane in the 4-position as potent inhibitors of mTOR with selectivity over PI3K[J]. Bioorganic & medicinal chemistry letters, 2010, 20(1): 375-379.  [Content Brief]