PI3K/mTOR-IN-23 dihydrochloride
Based on 1 Customer Validation
PI3K/mTOR-IN-23 dihydrochloride is a dual inhibitor of PI3K and mTOR with IC50 values of 49 and 41 nM. PI3K/mTOR-IN-23 dihydrochloride inhibits cancer cells proliferation.
For research use only. We do not sell to patients.
- Purity: 99.70%
- CAS No.: 1188890-32-5
- Formula: C16H17Cl2N3O2S
- Molecular Weight:386.30
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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mTOR 41 nM (IC50) |
PI3Kα 49 nM (IC50) |
PI3K/mTOR-IN-23 (Compound 1) dihydrochloride acts as a dual inhibitor of mTOR and PI3K-α in recombinant enzyme assays, with an mTOR IC50 of 49 nM, a PI3K-α IC50 of 41 nM[1].
PI3K/mTOR-IN-23 dihydrochloride inhibits LNCaP cell proliferation with an IC50 of 1300 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1188890-32-5
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Appearance Solid
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Molecular Weight 386.30
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Formula C16H17Cl2N3O2S
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Color White to off-white
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SMILES
OC1=CC(C2=NC(N3CCOCC3)=C4SC=CC4=N2)=CC=C1.Cl.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 10 mg/mL (25.89 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5887 mL | 12.9433 mL | 25.8866 mL | 64.7165 mL |
| 5 mM | 0.5177 mL | 2.5887 mL | 5.1773 mL | 12.9433 mL | |
| 10 mM | 0.2589 mL | 1.2943 mL | 2.5887 mL | 6.4717 mL | |
| 15 mM | 0.1726 mL | 0.8629 mL | 1.7258 mL | 4.3144 mL | |
| 20 mM | 0.1294 mL | 0.6472 mL | 1.2943 mL | 3.2358 mL | |
| 25 mM | 0.1035 mL | 0.5177 mL | 1.0355 mL | 2.5887 mL |
PI3K/mTOR-IN-23 dihydrochloride Related Classifications
HY-109633A Related Classifications
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