(S)-2-Amino-4,4,4-trifluorobutanoic acid (Synonyms: (2S)-2-Amino-4,4,4-trifluorobutanoic acid)

Cat. No.: HY-W078733: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

(S)-2-Amino-4,4,4-trifluorobutanoic acid ((2S)-2-Amino-4,4,4-trifluorobutanoic acid) is a Sestrin-GATOR2 modulator. (S)-2-Amino-4,4,4-trifluorobutanoic acid can be used in research on diabetes, neurodegenerative diseases, immune diseases, and cancer.

For research use only. We do not sell to patients.

(S)-2-Amino-4,4,4-trifluorobutanoic acid Chemical Structure

CAS No. : 15960-05-1

Size	Stock	Quantity
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

(S)-2-Amino-4,4,4-trifluorobutanoic acid (Compound I-4) (25 μM) does not act as a leucine mimetic or antagonist, showing a percentage activity relative to leucine between -40% and 40% in the Sestrin2-GATOR2 binding modulation assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

157.09

Formula

C₄H₆F₃NO₂

CAS No.

15960-05-1

Appearance

Solid

Color

White to off-white

SMILES

[C@H](CC(F)(F)F)(C(O)=O)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Purity: ≥98.0%

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Data Sheet (266 KB) SDS (394 KB)

COA (246 KB) HNMR (131 KB)

Handling Instructions (2659 KB)

References

[1]. Fetalvero Km, et al. Modulators of sestrin-gator2 interaction and uses thereof. United States, WO2017070518 A. 2017-04-27.

(S)-2-Amino-4,4,4-trifluorobutanoic acid Related Classifications

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-2-Amino-4,4,4-trifluorobutanoic acid15960-05-1(2S)-2-Amino-4,4,4-trifluorobutanoic acidmTORMammalian target of RapamycinleucineSestrin2-GATOR2thermal shift assaySestrin-GATOR2Inhibitorinhibitorinhibit

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