PI3K/mTOR Inhibitor-8
PI3K/mTOR Inhibitor-8 (Compound 18b) is a PI3K and mTOR dual inhibitor with IC50 values of 0.46 nM and 12 nM against PI3Kα and mTOR, respectively. PI3K/mTOR Inhibitor-8 induces HCT-116 cells apoptosis and arrests cell cycle at the G1/S phase.
For research use only. We do not sell to patients.
- CAS No.: 2492376-85-7
- Formula: C23H22N8O4S
- Molecular Weight:506.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PI3Kα 0.46 nM (IC50) |
mTOR 12 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
1.6 nM
Compound: 70
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Antiproliferative activity against human A549 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells measured after 72 hrs by MTT assay
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[PMID: 36503229] |
| HCT-116 | IC50 |
2 nM
Compound: 70
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Antiproliferative activity against human HCT-116 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells measured after 72 hrs by MTT assay
|
[PMID: 36503229] |
| MDA-MB-231 | IC50 |
16 nM
Compound: 70
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Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by MTT assay
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[PMID: 36503229] |
| PC-3 | IC50 |
2 nM
Compound: 70
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Antiproliferative activity against human PC-3 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human PC-3 cells measured after 72 hrs by MTT assay
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[PMID: 36503229] |
PI3K/mTOR Inhibitor-8 (Compound 18b) shows anti-proliferation activities with IC50 values of 1.95 ± 0.02, 2.02 ± 0.01, 1.62 ± 0.01 and 1.55 ± 0.01 μM against PC-3, HCT-116, A549 and MDA-MB-231 cells, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2492376-85-7
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Molecular Weight 506.54
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Formula C23H22N8O4S
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SMILES
O=C(C1=CC2=NC(C3=CN=C(N)N=C3)=NC(N4CCOCC4)=C2S1)NNC(C5=CC=C(OC)C=C5)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PI3K/mTOR Inhibitor-8 Related Classifications
HY-146200 Related Classifications
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