WYE-23
Based on 1 Customer Validation
WYE-23 is a mTOR inhibitor, and IC50 is 0.45 nM. It is selective to PI3Kα and IC50 is 661 nM. WYE-23 has antitumor activity.
For research use only. We do not sell to patients.
- Purity: 99.24%
- CAS No.: 1062169-46-3
- Formula: C26H32N8O4
- Molecular Weight:520.58
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
0.45 nM
Compound: 23
|
Inhibition of flag-tagged truncated human mTOR (1360-2549) expressed in HEK293 cells by DELFIA assay
Inhibition of flag-tagged truncated human mTOR (1360-2549) expressed in HEK293 cells by DELFIA assay
|
[PMID: 19645448] |
| HEK293 | IC50 |
0.5 nM
Compound: 25c
|
Inhibition of human mTOR (1360-2549 amino acids) expressed in HEK293 cells
Inhibition of human mTOR (1360-2549 amino acids) expressed in HEK293 cells
|
[PMID: 19894727] |
| LNCaP | IC50 |
42 nM
Compound: 23
|
Cytotoxicity against human LNCAP cells after 3 days by MTS assay
Cytotoxicity against human LNCAP cells after 3 days by MTS assay
|
[PMID: 19645448] |
| LNCaP | IC50 |
42 nM
Compound: 25c
|
Antiproliferative activity against human LNCAP cells after 3 days by MTS assay
Antiproliferative activity against human LNCAP cells after 3 days by MTS assay
|
[PMID: 19894727] |
Chemical Information
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CAS No. 1062169-46-3
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Appearance Solid
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Molecular Weight 520.58
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Formula C26H32N8O4
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Color White to off-white
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SMILES
O=C(N1CCC(N2N=CC3=C(N=C(N=C32)C4=CC=C(C=C4)NC(NC5CC5)=O)N6CCOCC6)CC1)OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Nikola P. Pavletich et al. mTOR CRYSTALS AND MODULATORS. WO2014176281A1.2014-10-30.
[2]. Zask A, et al. ATP-competitive inhibitors of the mammalian target of rapamycin: design and synthesis of highly potent and selective pyrazolopyrimidines. J Med Chem. 2009 Aug 27;52(16):5013-6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)