1062169-46-3
1062169-46-3
Chemical Structure
WYE-23
- CAS No.: 1062169-46-3
- Formula:C26H32N8O4
- Molecular Weight:520.58
IUPAC Name: methyl 4-(6-(4-(3-cyclopropylureido)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
InChIKey: NQNFBVOZVJAWSQ-UHFFFAOYSA-N
SMILES: O=C(N1CCC(N2N=CC3=C(N=C(N=C32)C4=CC=C(C=C4)NC(NC5CC5)=O)N6CCOCC6)CC1)OC
Biological Activity: WYE-23 is a mTOR inhibitor, and IC50 is 0.45 nM. It is selective to PI3Kα and IC50 is 661 nM. WYE-23 has antitumor activity[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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WYE-23 | 99.24% | WYE-23 is a mTOR inhibitor, and IC50 is 0.45 nM. It is selective to PI3Kα and IC50 is 661 nM. WYE-23 has antitumor activity. | ||||||||||||||||||||
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References
- [1]. Nikola P. Pavletich et al. mTOR CRYSTALS AND MODULATORS. WO2014176281A1.2014-10-30.
- [2]. Zask A, et al. ATP-competitive inhibitors of the mammalian target of rapamycin: design and synthesis of highly potent and selective pyrazolopyrimidines. J Med Chem. 2009 Aug 27;52(16):5013-6. [Content Brief]
