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Cat. No.: HY-139832

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MCX 28

MCX 28, a triple PI3K/mTOR/PIM inhibitor, displays low nanomolar activity.

For research use only. We do not sell to patients.

CAS No.: 1414453-58-9
Formula: C₂₅H₁₉N₅O₄S₃
Molecular Weight:549.64

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

MCX 28 Chemical Structure

CAS No.: 1414453-58-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

MCX 28, a triple PI3K/mTOR/PIM inhibitor, displays low nanomolar activity.

All PI3K Isoforms :

All mTOR Isoforms :

Chemical Information

CAS No. 1414453-58-9
Molecular Weight 549.64
Formula C₂₅H₁₉N₅O₄S₃
SMILES

CC1=C(C2=CN=C(OC)C(NS3(=O)=O)=C2)SC4=C1N=CN=C4C5=CC=C(CNC(C6=CC3=CC=C6)=O)S5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Martínez-González S, et al. Macrocyclization as a Source of Desired Polypharmacology. Discovery of Triple PI3K/mTOR/PIM Inhibitors. ACS Med Chem Lett. 2021 Nov 2;12(11):1794-1801. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
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Chemical Information
Purity & Documentation
References

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MCX 28

All PI3K Isoforms

All mTOR Isoforms