NS1-IN-1
Based on 1 publication(s) in Google Scholar
NS1-IN-1 (REDD1 inducer-1) is a naphthalimide compound and an NS1 inhibitor. NS1-IN-1 antagonizes influenza A virus NS1-mediated inhibition of host gene expression and induces REDD1 expression. NS1-IN-1 suppresses the mTORC1 signaling pathway via a TSC1-TSC2 dependent mechanism. NS1-IN-1 exhibits broad antiviral activity against influenza virus and vesicular stomatitis virus (VSV), with low toxicity.
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- CAS No.: 181373-35-3
- Formula: C23H26N2O4
- Molecular Weight:394.46
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Publications Citing Use of MedChemExpress (MCE) NS1-IN-1
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Biological Activity
NS1-IN-1 (compound 3) (25-50 μM; 24-30 h) reduces influenza virus replication and viral protein expression (NP, M1, etc.) in MDCK cells with low cytotoxicity, consistent with cell viability assay showing CC50/IC50 ≈ 31[1].
NS1-IN-1 (30 μM; 4-9 h) inhibits influenza viral protein expression and induces REDD1 in A549 cells, while suppressing mTORC1 signaling via a TSC1-TSC2 dependent mechanism[1].
NS1-IN-1 (30 μM; up to 18 h) transcriptionally induces REDD1 mRNA without activating IFN-β or ISGs, confirming a non-interferon antiviral mechanism[1].
NS1-IN-1 (25-50 μM; 24 h) also inhibits VSV infection in MDCK cells, with antiviral activity dependent on the REDD1-TSC1-TSC2-mTORC1 axis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDCK, MEF, HBEC cells
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Concentration:0.2-100 μM
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Incubation Time:24-72 h
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Result:Showed low cytotoxicity in host cells, with CC50/IC50 selectivity ratio of approximately 31.
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Cell Line:MDCK, A549 cells
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Concentration:30 μM
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Incubation Time:4-9 h post-infection
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Result:Downregulated influenza viral proteins (NS1, NP, M1, etc.) and induced REDD1 protein (6-8 fold).
Reduced S6K phosphorylation at Thr389 (mTORC1 inhibition) without directly affecting AKT in early stages.
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Cell Line:A549 cell
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Concentration:30 μM
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Incubation Time:Various time points (up to 18 h pretreatment + infection)
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Result:Transcriptionally induced REDD1 mRNA expression; induction was abolished by actinomycin D.
Did not induce IFN-β or interferon-stimulated genes.
Chemical Information
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CAS No. 181373-35-3
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Molecular Weight 394.46
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Formula C23H26N2O4
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SMILES
O=C(O)CCCCCN(C(C1=CC=C(N2CCCCC2)C3=CC=CC4=C13)=O)C4=O
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Synonyms
REDD1 inducer-1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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J Neuroinflammation
Microglial SIRT1 activation attenuates synapse loss in retinal inner plexiform layer via mTORC1 inhibition. [Abstract]2023 Sep 5;20(1):202. PMID: 37670386
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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