181373-35-3
Chemical Structure
NS1-IN-1
Synonym(s): REDD1 inducer-1
- CAS No.: 181373-35-3
- Formula:C23H26N2O4
- Molecular Weight:394.46
IUPAC Name: 6-(1,3-dioxo-6-(piperidin-1-yl)-1H-benzo[de]isoquinolin-2(3H)-yl)hexanoic acid
InChIKey: MBIOYMJZOCQPAE-UHFFFAOYSA-N
SMILES: O=C(O)CCCCCN(C(C1=CC=C(N2CCCCC2)C3=CC=CC4=C13)=O)C4=O
Biological Activity: NS1-IN-1 (REDD1 inducer-1) is a naphthalimide compound and an NS1 inhibitor. NS1-IN-1 antagonizes influenza A virus NS1-mediated inhibition of host gene expression and induces REDD1 expression. NS1-IN-1 suppresses the mTORC1 signaling pathway via a TSC1-TSC2 dependent mechanism. NS1-IN-1 exhibits broad antiviral activity against influenza virus and vesicular stomatitis virus (VSV), with low toxicity[1].
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NS1-IN-1 | NS1-IN-1 (REDD1 inducer-1) is a naphthalimide compound and an NS1 inhibitor. NS1-IN-1 antagonizes influenza A virus NS1-mediated inhibition of host gene expression and induces REDD1 expression. NS1-IN-1 suppresses the mTORC1 signaling pathway via a TSC1-TSC2 dependent mechanism. NS1-IN-1 exhibits broad antiviral activity against influenza virus and vesicular stomatitis virus (VSV), with low toxicity. | |||||||||||||||||||||
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