Antiproliferative agent-57
Antiproliferative agent-57 (compound M2) is a tumor angiogenesis inhibitor. Antiproliferative agent-57 inhibits the secretion of VEGF in SiHa cells under hypoxic conditions (IC50=0.68 μM) without inducing cytotoxicity. Antiproliferative agent-57 can modulate the PI3K/AKT/mTOR and MAPK signaling pathways in tumor cells to inhibit the expression of HIF-1α and VEGF in tumor tissues.
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- Formule: C34H37ClN4O9
- Masse moléculaire:681.13
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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- Pureté et documentation
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Activité biologique
Description
Chemical Information
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Masse moléculaire 681.13
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Formule C34H37ClN4O9
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SMILES
COC(C1=CC[C@@]2(C(O[C@](C)(/C=C/C=C(C)/C(OCC(NCC3=CN(C4=CC=C(Cl)C=C4)N=N3)=O)=O)[C@]5([H])CC2)=O)[C@]5(OC(C)=O)CC1)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Deng H, et al. Design, Synthesis, and Evaluation of Antitumor Activity in Pseudolaric acid B Azole Derivatives: Novel and potent Angiogenesis inhibitor via Regulation of the PI3K/AKT and MAPK Mediated HIF-1/VEGF Signaling Pathway[J]. European Journal of Medicinal Chemistry, 2024: 116813. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antiproliferative agent-57 Related Classifications
HY-169100 Related Classifications
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Keywords
- Antiproliferative agent-57
- Antiproliferative agent57
- Antiproliferative agent 57
- VEGFR
- PI3K
- Akt
- mTOR
- p38 MAPK
- HIF/HIF Prolyl-Hydroxylase
- Vascular endothelial growth factor receptor
- Phosphoinositide 3-kinase
- PKB
- Protein kinase B
- Mammalian target of Rapamycin
- Hypoxia-inducible factors
- HIFs
- HIF-PH
- Angiogenesis
- Inhibitors
- SiHa cells
- Cytotoxicity
- Hypoxia
- Inhibitor
- inhibitor
- inhibit