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  3. FT-1518

FT-1518 

Cat. No.: HY-107363
Handling Instructions

FT-1518 is a new generation selective, potent and oral bioavailable mTORC1 and mTORC2 inhibitor, and exhibits antitumor activity.

For research use only. We do not sell to patients.

FT-1518 Chemical Structure

FT-1518 Chemical Structure

CAS No. : 1313026-58-2

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Description

FT-1518 is a new generation selective, potent and oral bioavailable mTORC1 and mTORC2 inhibitor, and exhibits antitumor activity.

IC50 & Target[1]

mTORC1

 

mTORC2

 

In Vitro

FT-1518 is a new generation selective, potent and oral bioavailable mTORC1 and mTORC2 inhibitor, and exhibits antitumor activity. FT-1518 displays significant growth inhibitory activity against a large panel of hematologic and solid tumor cell lines with most activities falling into low nanomolar range. FT-1518 cuases potent inhibition of the mTOR pathway biomarkers (mTORC 1 & 2 biomarkers [pAkt(S473) and pS6(S240/244) or p70 S6K), no inhibition of PI3K biomarker [pAkt(T308)] in cells[1].

In Vivo

FT-1518 exhibits dose-dependent and higher tumor growth inhibition (TGI) in multiple solid tumor xenografts[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

394.47

Formula

C₂₀H₂₆N₈O

CAS No.

1313026-58-2

SMILES

CCC(N1C2=NC(N3CC4OC(CC4)C3)=NC(C5=NC=C(N)N=C5)=C2N=C1)CC

Shipping

Room temperature in continental US; may vary elsewhere

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FT-1518
Cat. No.:
HY-107363
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FT-1518

Cat. No.: HY-107363