Pnpla3 - patatin-like phospholipase domain containing 3 Gene

Also Known as Adpn

Species: Mus musculus

Gene Type: protein coding
Gene ID: 116939

Summary

Enables several functions, including 1-acylglycerol-3-phosphate O-acyltransferase activity; long-chain fatty acyl-CoA binding activity; and lysophosphatidic acid binding activity. Involved in glycerolipid metabolic process; long-chain fatty acid metabolic process; and response to dietary excess. Located in lipid droplet and membrane. Is expressed in left lung; olfactory epithelium; and right lung. Used to study non-alcoholic fatty liver disease. Human ortholog(s) of this gene implicated in coronary artery disease; fatty liver disease (multiple); liver disease (multiple); and type 2 diabetes mellitus. Orthologous to human PNPLA3 (patatin like Phospholipase domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]

Pnpla3 Products (5)

mRNA Protein Name
NM_001408339.1 NP_001395268.1 1-acylglycerol-3-phosphate O-acyltransferase Pnpla3 isoform 2
NM_001408340.1 NP_001395269.1 1-acylglycerol-3-phosphate O-acyltransferase Pnpla3 isoform 3
NM_001408341.1 NP_001395270.1 1-acylglycerol-3-phosphate O-acyltransferase Pnpla3 isoform 4
NM_001408342.1 NP_001395271.1 1-acylglycerol-3-phosphate O-acyltransferase Pnpla3 isoform 5
NM_054088.4 NP_473429.2 1-acylglycerol-3-phosphate O-acyltransferase Pnpla3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 1-acylglycerol-3-phosphate O-acyltransferase activity IDA
IDA: Inferred from direct assay
22560221 MGI
enables long-chain fatty acyl-CoA binding IDA
IDA: Inferred from direct assay
22560221 MGI
enables lysophosphatidic acid acyltransferase activity IDA
IDA: Inferred from direct assay
22560221 MGI
enables lysophosphatidic acid binding IDA
IDA: Inferred from direct assay
22560221 MGI
enables triacylglycerol lipase activity IDA
IDA: Inferred from direct assay
22560221 MGI
Biological Process GO Annotation Evidence References Source
involved in glycerophospholipid metabolic process IDA
IDA: Inferred from direct assay
22560221 MGI
involved in long-chain fatty acid metabolic process IDA
IDA: Inferred from direct assay
22560221 MGI
involved in phosphatidic acid biosynthetic process IDA
IDA: Inferred from direct assay
22560221 MGI
involved in response to dietary excess IMP
IMP: Inferred from mutant phenotype
22560221 MGI
involved in triglyceride biosynthetic process IDA
IDA: Inferred from direct assay
22560221 MGI
involved in triglyceride catabolic process IDA
IDA: Inferred from direct assay
22560221 MGI
Cellular Component GO Annotation Evidence References Source
located in lipid droplet IDA
IDA: Inferred from direct assay
22560221 MGI
located in membrane IDA
IDA: Inferred from direct assay
11431482 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

1-acylglycerol-3-phosphate O-acyltransferase Pnpla3

  • acylglycerol O-acyltransferase

  • acylglycerol transacylase

  • adiponutrin

  • calcium-independent phospholipase A2-epsilon

  • iPLA2-epsilon

  • lysophosphatidic acid acyltransferase

  • patatin-like phospholipase domain-containing protein 3

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-163959 PF-07853578 Modulator 99.08% Phase 1

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N1967 Dihydrocurcumin Modulator 99.58% Unkown
HY-177628 Edutirsen Inhibitor 98.52% Unkown
HY-RS10794 PNPLA3 Human Pre-designed siRNA Set A / Unkown
HY-173599 NUV-244 Inhibitor / Unkown
HY-177628A Edutirsen sodium Inhibitor / Unkown
HY-159656 PNPLA3 modifier 1 Modulator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pnpla3 NCBI NCBI:80339