Pnpla3 - patatin-like phospholipase domain containing 3 Gene

Mus musculus

Also known as Adpn

Gene ID: 116939 | Gene type: protein coding

About Pnpla3

Summary

Enables several functions, including 1-acylglycerol-3-phosphate O-acyltransferase activity; long-chain fatty acyl-CoA binding activity; and lysophosphatidic acid binding activity. Involved in glycerolipid metabolic process; long-chain fatty acid metabolic process; and response to dietary excess. Located in lipid droplet and membrane. Is expressed in left lung; olfactory epithelium; and right lung. Used to study non-alcoholic fatty liver disease. Human ortholog(s) of this gene implicated in coronary artery disease; fatty liver disease (multiple); liver disease (multiple); and type 2 diabetes mellitus. Orthologous to human PNPLA3 (patatin like Phospholipase domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]

Pnpla3 Products(5)

mRNA	Protein	Name
NM_001408339.1	NP_001395268.1	1-acylglycerol-3-phosphate O-acyltransferase Pnpla3 isoform 2
NM_001408340.1	NP_001395269.1	1-acylglycerol-3-phosphate O-acyltransferase Pnpla3 isoform 3
NM_001408341.1	NP_001395270.1	1-acylglycerol-3-phosphate O-acyltransferase Pnpla3 isoform 4
NM_001408342.1	NP_001395271.1	1-acylglycerol-3-phosphate O-acyltransferase Pnpla3 isoform 5
NM_054088.4	NP_473429.2	1-acylglycerol-3-phosphate O-acyltransferase Pnpla3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 1-acylglycerol-3-phosphate O-acyltransferase activity	IDA IDA: Inferred from direct assay	22560221	MGI
enables long-chain fatty acyl-CoA binding	IDA IDA: Inferred from direct assay	22560221	MGI
enables lysophosphatidic acid acyltransferase activity	IDA IDA: Inferred from direct assay	22560221	MGI
enables lysophosphatidic acid binding	IDA IDA: Inferred from direct assay	22560221	MGI
enables triacylglycerol lipase activity	IDA IDA: Inferred from direct assay	22560221	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in glycerophospholipid metabolic process	IDA IDA: Inferred from direct assay	22560221	MGI
involved in long-chain fatty acid metabolic process	IDA IDA: Inferred from direct assay	22560221	MGI
involved in phosphatidic acid biosynthetic process	IDA IDA: Inferred from direct assay	22560221	MGI
involved in response to dietary excess	IMP IMP: Inferred from mutant phenotype	22560221	MGI
involved in triglyceride biosynthetic process	IDA IDA: Inferred from direct assay	22560221	MGI
involved in triglyceride catabolic process	IDA IDA: Inferred from direct assay	22560221	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in lipid droplet	IDA IDA: Inferred from direct assay	22560221	MGI
located in membrane	IDA IDA: Inferred from direct assay	11431482	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

1-acylglycerol-3-phosphate O-acyltransferase Pnpla3

acylglycerol O-acyltransferase	acylglycerol transacylase
adiponutrin	calcium-independent phospholipase A2-epsilon
iPLA2-epsilon	lysophosphatidic acid acyltransferase
patatin-like phospholipase domain-containing protein 3

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-163959	PF-07853578	Modulator	99.08%	Phase 1

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N1967	Dihydrocurcumin	Modulator	99.58%	Unkown
HY-177628	Edutirsen	Inhibitor	98.52%	Unkown
HY-RS10794	PNPLA3 Human Pre-designed siRNA Set A		/	Unkown
HY-173599	NUV-244	Inhibitor	/	Unkown
HY-177628A	Edutirsen sodium	Inhibitor	/	Unkown
HY-159656	PNPLA3 modifier 1	Modulator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pnpla3	NCBI	NCBI:80339

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