Cyp11a1 - cytochrome P450, family 11, subfamily a, polypeptide 1 Gene

Also Known as Scc; cscc; Cyp11a; Cypxia1; P450scc; D9Ertd411e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13070

Summary

Enables Cholesterol monooxygenase (side-chain-cleaving) activity. Acts upstream of or within C21-steroid hormone biosynthetic process. Located in mitochondrion. Is expressed in several structures, including endocrine gland; labyrinthine zone; reproductive system; spleen; and urinary system. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia and congenital adrenal insufficiency. Orthologous to human CYP11A1 (Cytochrome P450 family 11 subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]

Cyp11a1 Products (2)

mRNA Protein Name
NM_001346787.1 NP_001333716.1 cholesterol side-chain cleavage enzyme, mitochondrial isoform 2
NM_019779.4 NP_062753.3 cholesterol side-chain cleavage enzyme, mitochondrial isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cholesterol monooxygenase (side-chain-cleaving) activity IDA
IDA: Inferred from direct assay
7527351 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within C21-steroid hormone biosynthetic process IDA
IDA: Inferred from direct assay
7527351 MGI
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
8111631 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cholesterol side-chain cleavage enzyme, mitochondrial

  • cholesterol desmolase

  • cytochrome P450 11A1

  • cytochrome P450 side-chain cleavage enzyme

  • cytochrome P450(scc)

  • cytochrome P450, 11a, cholesterol side-chain cleavage

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16276 Osilodrostat Inhibitor 99.90% Yes
HY-16276A Osilodrostat phosphate Inhibitor 98.83% Yes

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-156628 Opevesostat Inhibitor 99.79% Phase 3

Pre-clinical Phase

Bioactive Molecules (19)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-130705A Tachysterol 3 99.68% Unkown
HY-B0105B Levoketoconazole Inhibitor 99.82% Unkown
HY-103322 6-Bnz-cAMP sodium salt 98.5% Unkown
HY-156530 CYP11A1-IN-1 Inhibitor 98.90% Unkown
HY-W679754 Pentacosafluorotridecanoic Acid Inhibitor 95.0% Unkown
HY-101217 BI 689648 Inhibitor 99.20% Unkown
HY-135281 CYP11B2-IN-1 Inhibitor 99.83% Unkown
HY-122744 CYP11B1-IN-1 Inhibitor / Unkown
HY-151140 CYP11B1-IN-2 Inhibitor / Unkown
HY-176480 CYP11B2-IN-3 Inhibitor / Unkown
HY-179686 CYP11A1-IN-2 Inhibitor / Unkown
HY-181747 CYP11A1-IN-3 Inhibitor / Unkown
HY-RS03434 CYP11A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03435 CYP11B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-163751 STING-IN-9 Inhibitor / Unkown
HY-RS17315 Cyp11b1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17479 Cyp11a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23770 Cyp11b1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23937 Cyp11a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cyp11a1 NCBI NCBI:1583