CYP11A1-IN-3
CYP11A1-IN-3 (Compound II-4) is a selective CYP11A1 inhibitor with an IC50 of 26.7 nM. CYP11A1-IN-3 shows selectivity towards CYP1A2, 2C9 and 2D6. CYP11A1-IN-3 can be used for the research of castration-resistant prostate cancer.
For research use only. We do not sell to patients.
- Formula: C23H31N3O5S
- Molecular Weight:461.57
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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CYP11A1 26.7 nM (IC50) |
CYP11A1-IN-3 (II-4) (100-1000 nM; 3000 nM starting for IC50) potently inhibits CYP11A1 activity with an IC50 of 26.7 nM, achieving 97.0% and 95.2% inhibition at 1000 nM and 100 nM, respectively, in human ovarian granulosa-like tumor (KGN) cells[1].
CYP11A1-IN-3 (II-4) (10 μM) exhibits minimal inhibition of major CYP isoforms, with 2.9% inhibition of CYP1A2, 4.9% inhibition of CYP2C9, 16.6% inhibition of CYP2C19, 6.6% inhibition of CYP2D6, and no inhibition of CYP3A4/5 in human liver microsomes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 461.57
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Formula C23H31N3O5S
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SMILES
CC1=C(C(C=C(O1)CN2CC3=C(C2)C=CC=C3)=O)OCC4CCN(CC4)S(=O)(N(C)C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CYP11A1-IN-3 Related Classifications
HY-181747 Related Classifications
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