CYP11A1-IN-3 

CYP11A1-IN-3 (Compound II-4) is a selective CYP11A1 inhibitor with an IC₅₀ of 26.7 nM. CYP11A1-IN-3 shows selectivity towards CYP1A2, 2C9 and 2D6. CYP11A1-IN-3 can be used for the research of castration-resistant prostate cancer^[1].

CYP11A1-IN-3 (II-4) (100-1000 nM; 3000 nM starting for IC₅₀) potently inhibits CYP11A1 activity with an IC₅₀ of 26.7 nM, achieving 97.0% and 95.2% inhibition at 1000 nM and 100 nM, respectively, in human ovarian granulosa-like tumor (KGN) cells^[1].
CYP11A1-IN-3 (II-4) (10 μM) exhibits minimal inhibition of major CYP isoforms, with 2.9% inhibition of CYP1A2, 4.9% inhibition of CYP2C9, 16.6% inhibition of CYP2C19, 6.6% inhibition of CYP2D6, and no inhibition of CYP3A4/5 in human liver microsomes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

461.57

C₂₃H₃₁N₃O₅S

CC1=C(C(C=C(O1)CN2CC3=C(C2)C=CC=C3)=O)OCC4CCN(CC4)S(=O)(N(C)C)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wang D, et al. Design, synthesis, and biological evaluation of cytochrome P450 CYP11A1 inhibitors. Bioorg Med Chem Lett. 2026;135:130567.  [Content Brief]