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Cat. No.: HY-181747

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CYP11A1-IN-3

CYP11A1-IN-3 (Compound II-4) is a selective CYP11A1 inhibitor with an IC₅₀ of 26.7 nM. CYP11A1-IN-3 shows selectivity towards CYP1A2, 2C9 and 2D6. CYP11A1-IN-3 can be used for the research of castration-resistant prostate cancer.

For research use only. We do not sell to patients.

Formula: C₂₃H₃₁N₃O₅S
Molecular Weight:461.57

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

CYP11A1-IN-3 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

CYP11A1

26.7 nM (IC₅₀)

All Cytochrome P450 Isoforms :

In Vitro

CYP11A1-IN-3 (II-4) (100-1000 nM; 3000 nM starting for IC₅₀) potently inhibits CYP11A1 activity with an IC₅₀ of 26.7 nM, achieving 97.0% and 95.2% inhibition at 1000 nM and 100 nM, respectively, in human ovarian granulosa-like tumor (KGN) cells^[1].
CYP11A1-IN-3 (II-4) (10 μM) exhibits minimal inhibition of major CYP isoforms, with 2.9% inhibition of CYP1A2, 4.9% inhibition of CYP2C9, 16.6% inhibition of CYP2C19, 6.6% inhibition of CYP2D6, and no inhibition of CYP3A4/5 in human liver microsomes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

Molecular Weight 461.57
Formula C₂₃H₃₁N₃O₅S
SMILES

CC1=C(C(C=C(O1)CN2CC3=C(C2)C=CC=C3)=O)OCC4CCN(CC4)S(=O)(N(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang D, et al. Design, synthesis, and biological evaluation of cytochrome P450 CYP11A1 inhibitors. Bioorg Med Chem Lett. 2026;135:130567. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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