LRGUK - leucine rich repeats and guanylate kinase domain containing Gene

Also Known as CFAP246

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 136332

About LRGUK

Cytogenetic location: 7q33 Genomic coordinates (GRCh38): 7:134,127,340-134,276,685 (from NCBI)

This gene has 5 transcripts (splice variants), 193 orthologues and 13 paralogues. Biased expression in testis (RPKM 1.3), lung (RPKM 0.2) and 7 other tissues.

Summary

Predicted to enable guanylate kinase activity. Predicted to be involved in axoneme assembly and spermatogenesis. Predicted to be located in acrosomal vesicle and manchette. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

LRGUK Products (4)

mRNA Protein Name
NM_001365700.3 NP_001352629.1 leucine-rich repeat and guanylate kinase domain-containing protein isoform 1
NM_001365701.3 NP_001352630.1 leucine-rich repeat and guanylate kinase domain-containing protein isoform 2
NM_001401519.1 NP_001388448.1 leucine-rich repeat and guanylate kinase domain-containing protein isoform 4
NM_144648.3 NP_653249.1 leucine-rich repeat and guanylate kinase domain-containing protein isoform 3

LRGUK Protein Structure

(150 - 164)

LRR_9

LRR_9: Leucine-rich repeat (264 - 375)

Guanylate_kin

Guanylate_kin: Guanylate kinase (416 - 598)

  • 0
  • 200
  • 400
  • 600
  • 825 a.a.
Protein Preferred Names Protein Names

leucine-rich repeat and guanylate kinase domain-containing protein

LRGUK Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LRGUK Q96M69 HOOK2 Homo sapiens Q96ED9-2
Y2H Array
32296183
Intra
LRGUK Q96M69 HOOK2 Homo sapiens Q96ED9-2
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spermatogenic Failure

  • Azoospermia

  • Spgf

  • Spermatogenic Failure, Susceptibility To

  • Absent Sperm

  • Aspermatogenesis

  • Infertility Due To Azoospermia

  • Hypospermatogenesis

  • Azoospermatism
Primary Ciliary Dyskinesia

  • Immotile Cilia Syndrome

  • Kartagener Syndrome

  • Dextrocardia Bronchiectasis And Sinusitis

  • Pcd

  • Ciliary Motility Disorders

  • Ciliary Motility Disorder

  • Immotile Ciliary Syndrome

  • Ciliary Dyskinesia Primary

  • Ics

  • Polynesian Bronchiectasis

  • Dextrocardia-Bronchiectasis-Sinusitis Syndrome

  • Immotile Cilia Syndrome, Kartagener Type

  • Primary Ciliary Dyskinesia And Situs Inversus

  • Primary Ciliary Dyskinesia, Kartagener Type

  • Siewert Syndrome

  • Dyskinesia, Ciliary, Primary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07785 LRGUK Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta LRGUK VGNC VGNC:74334
Mus musculus LRGUK MGD MGI:1921604
Felis catus LRGUK VGNC VGNC:63279
Rattus norvegicus LRGUK RGD RGD:1308226
Bos taurus LRGUK VGNC VGNC:52794
Canis familiaris LRGUK VGNC VGNC:54786
Others LRGUK NCBI