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Fcer1g - Fc receptor, IgE, high affinity I, gamma polypeptide Gene

Also Known as CD23; Fce1g; Ly-50; FcR[g]; FcRgamma; FcR-gamma; FcepsilonRI

Species: Mus musculus

Gene Type: protein coding

Gene ID: 14127

Summary

Enables IgE receptor activity; IgG binding activity; and identical protein binding activity. Contributes to IgE binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of interleukin-4 production; and serotonin secretion by platelet. Acts upstream of or within several processes, including leukocyte differentiation; positive regulation of cytokine production; and positive regulation of immune response. Located in external side of plasma membrane. Is integral component of plasma membrane. Part of Fc-epsilon Receptor I complex. Is expressed in central nervous system; gut; male reproductive gland or organ; and retina. Orthologous to human FCER1G (Fc fragment of IgE receptor Ig). [provided by Alliance of Genome Resources, Apr 2022]

Fcer1g Products (1)

mRNA	Protein	Name
NM_010185.4	NP_034315.1	high affinity immunoglobulin epsilon receptor subunit gamma precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
contributes to IgE binding	IDA IDA: Inferred from direct assay	14764707	MGI
enables IgE binding	IDA IDA: Inferred from direct assay	2527850	MGI
contributes to IgE binding	IMP IMP: Inferred from mutant phenotype	14764707	MGI
enables IgE receptor activity	IDA IDA: Inferred from direct assay	14764707	MGI
enables IgE receptor activity	IMP IMP: Inferred from mutant phenotype	14764707	MGI
enables IgG binding	IMP IMP: Inferred from mutant phenotype	14643301	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	15184345	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12893283	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within Fc receptor mediated stimulatory signaling pathway	IMP IMP: Inferred from mutant phenotype	14764707	MGI
acts upstream of or within Fc-gamma receptor signaling pathway	IDA IDA: Inferred from direct assay	23602766	MGI
acts upstream of or within T cell differentiation involved in immune response	IMP IMP: Inferred from mutant phenotype	23602766	MGI
acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class I	IMP IMP: Inferred from mutant phenotype	11911824	MGI
acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II	IMP IMP: Inferred from mutant phenotype	14643301	MGI
acts upstream of or within cell surface receptor signaling pathway	IEP IEP: Inferred from expression pattern	9000133	MGI
acts upstream of or within cell surface receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	11911823	MGI
involved in cellular response to low-density lipoprotein particle stimulus	IDA IDA: Inferred from direct assay	23395392	MGI
acts upstream of or within defense response to bacterium	IMP IMP: Inferred from mutant phenotype	11237803	MGI
acts upstream of or within immunoglobulin mediated immune response	IMP IMP: Inferred from mutant phenotype	10395649	MGI
acts upstream of or within innate immune response	IMP IMP: Inferred from mutant phenotype	23602766	MGI
involved in integrin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	17086186	MGI
acts upstream of or within interleukin-2 production	IPI IPI: Inferred from physical interaction	15184345	MGI
involved in interleukin-3-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	19098920	MGI
acts upstream of interleukin-6 production	IDA IDA: Inferred from direct assay	14764707	MGI
acts upstream of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	14764707	MGI
acts upstream of or within mast cell activation	IDA IDA: Inferred from direct assay	14764707	MGI
acts upstream of or within mast cell activation	IMP IMP: Inferred from mutant phenotype	14764707	MGI
acts upstream of mast cell apoptotic process	IDA IDA: Inferred from direct assay	14764707	MGI
acts upstream of mast cell apoptotic process	IMP IMP: Inferred from mutant phenotype	14764707	MGI
acts upstream of mast cell cytokine production	IDA IDA: Inferred from direct assay	14764707	MGI
acts upstream of mast cell cytokine production	IMP IMP: Inferred from mutant phenotype	14764707	MGI
acts upstream of mast cell degranulation	IDA IDA: Inferred from direct assay	14764707	MGI
acts upstream of mast cell degranulation	IMP IMP: Inferred from mutant phenotype	14764707	MGI
acts upstream of or within negative regulation of mast cell apoptotic process	IDA IDA: Inferred from direct assay	14764707	MGI
acts upstream of or within negative regulation of mast cell apoptotic process	IMP IMP: Inferred from mutant phenotype	14764707	MGI
involved in neutrophil activation involved in immune response	IMP IMP: Inferred from mutant phenotype	17086186	MGI
acts upstream of or within neutrophil chemotaxis	IMP IMP: Inferred from mutant phenotype	8976192	MGI
acts upstream of or within osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	21841309	MGI
acts upstream of or within phagocytosis, engulfment	IMP IMP: Inferred from mutant phenotype	11237803	MGI
acts upstream of or within positive regulation of immune response	IMP IMP: Inferred from mutant phenotype	10395649	MGI
acts upstream of or within positive regulation of interleukin-10 production	IMP IMP: Inferred from mutant phenotype	11911824	MGI
involved in positive regulation of interleukin-4 production	IMP IMP: Inferred from mutant phenotype	19098920	MGI
acts upstream of or within positive regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	14764707	MGI
acts upstream of or within positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	14764707	MGI
acts upstream of or within positive regulation of mast cell cytokine production	IDA IDA: Inferred from direct assay	14764707	MGI
acts upstream of or within positive regulation of mast cell cytokine production	IMP IMP: Inferred from mutant phenotype	14764707	MGI
acts upstream of or within positive regulation of mast cell degranulation	IDA IDA: Inferred from direct assay	14764707	MGI
acts upstream of or within positive regulation of mast cell degranulation	IMP IMP: Inferred from mutant phenotype	14764707	MGI
acts upstream of or within positive regulation of phagocytosis	IMP IMP: Inferred from mutant phenotype	11237803	MGI
acts upstream of or within positive regulation of protein localization to cell surface	IDA IDA: Inferred from direct assay	15184345	MGI
acts upstream of or within positive regulation of protein localization to cell surface	IMP IMP: Inferred from mutant phenotype	15184345	MGI
acts upstream of or within positive regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	14764707	MGI
acts upstream of or within positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	10229794	MGI
acts upstream of or within positive regulation of type I hypersensitivity	IMP IMP: Inferred from mutant phenotype	14764707	MGI
acts upstream of or within positive regulation of type III hypersensitivity	IMP IMP: Inferred from mutant phenotype	8976192	MGI
acts upstream of or within positive regulation of type IIa hypersensitivity	IMP IMP: Inferred from mutant phenotype	8976192	MGI
acts upstream of or within protein localization to plasma membrane	IDA IDA: Inferred from direct assay	17543387	MGI
involved in receptor internalization	IDA IDA: Inferred from direct assay	23395392	MGI
acts upstream of or within regulation of immune response	IMP IMP: Inferred from mutant phenotype	11911824	MGI
involved in regulation of platelet activation	IMP IMP: Inferred from mutant phenotype	9171347	MGI
involved in serotonin secretion by platelet	IMP IMP: Inferred from mutant phenotype	9171347	MGI
acts upstream of or within signal transduction	IDA IDA: Inferred from direct assay	12192036	MGI
acts upstream of tumor necrosis factor production	IDA IDA: Inferred from direct assay	14764707	MGI
acts upstream of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	14764707	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of Fc-epsilon receptor I complex	IMP IMP: Inferred from mutant phenotype	14764707	MGI
located in cell surface	IDA IDA: Inferred from direct assay	15184345	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	2527850	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	2527850	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
high affinity immunoglobulin epsilon receptor subunit gamma	Fc receptor gamma-chain fc-epsilon RI-gamma fceRI gamma igE Fc receptor subunit gamma

Fcer1g Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Fcer1g	P20491	Jak2	Mus musculus	Q62120	Anti Tag CoIP	24608040

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04823	FCER1G Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fcer1g	NCBI	NCBI:2207