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CITED4 - Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 163732

About CITED4

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:40,861,054-40,862,363 (from NCBI)

This gene has 1 transcript (splice variant), 228 orthologues and 2 paralogues.

Summary

The protein encoded by this intronless gene belongs to the CITED family of transcriptional coactivators that bind to several proteins, including CREB-binding protein (CBP) and p300, via a conserved 32 aa C-terminal motif, and regulate gene transcription. This protein also interacts with transcription factor AP2 (TFAP2), and thus may function as a co-activator for TFAP2. Hypermethylation and transcriptional downregulation of this gene has been observed in oligodendroglial tumors with deletions of chromosomal arms 1p and 19q, and associated with longer recurrence-free and overall survival of patients with oligodendroglial tumors. [provided by RefSeq, Aug 2011]

CITED4 Products (1)

mRNA	Protein	Name
NM_133467.3	NP_597724.1	cbp/p300-interacting transactivator 4

CITED4 Protein Structure

CITED

0
100
184 a.a.

Protein Preferred Names	Protein Names
cbp/p300-interacting transactivator 4	MRG-2

Related Diseases

Diseases	Alias
Adult Oligodendroglioma	Adult Brain Oligodendroglioma Grade Ii Adult Oligodendroglial Tumor Oligodendroglioma, Adult
Photoallergic Dermatitis	Dermatitis, Photoallergic Photoallergic Contact Dermatitis Photoallergic Eczema Photo-Allergic Contact Eczema
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02730	CITED4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CITED4	VGNC	VGNC:27378
Rattus norvegicus	CITED4	RGD	RGD:620113
Macaca mulatta	CITED4	VGNC	VGNC:99867
Mus musculus	CITED4	MGD	MGI:1861694
Felis catus	CITED4	VGNC	VGNC:107511
Others	CITED4	NCBI