Khk - ketohexokinase Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16548

Summary

Enables Ketohexokinase activity. Acts upstream of or within fructose metabolic process and regulation of glycogen metabolic process. Located in cytoplasm and nucleus. Is expressed in alimentary system; central nervous system; liver; and retina. Human ortholog(s) of this gene implicated in essential fructosuria. Orthologous to human KHK (Ketohexokinase). [provided by Alliance of Genome Resources, Apr 2022]

Khk Products (4)

mRNA Protein Name
NM_001310524.1 NP_001297453.1 ketohexokinase isoform 1
NM_001310525.1 NP_001297454.1 ketohexokinase isoform 3
NM_001349066.1 NP_001335995.1 ketohexokinase isoform 4
NM_008439.4 NP_032465.2 ketohexokinase isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ketohexokinase activity IDA
IDA: Inferred from direct assay
15652177 MGI
enables ketohexokinase activity IMP
IMP: Inferred from mutant phenotype
28194018 MGI
Biological Process GO Annotation Evidence References Source
involved in fructose catabolic process IDA
IDA: Inferred from direct assay
4343087 MGI
involved in fructose catabolic process IMP
IMP: Inferred from mutant phenotype
23813872 MGI
involved in fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate IMP
IMP: Inferred from mutant phenotype
23813872 MGI
acts upstream of or within fructose metabolic process IMP
IMP: Inferred from mutant phenotype
22371574 MGI
acts upstream of or within regulation of glycogen metabolic process IMP
IMP: Inferred from mutant phenotype
22371574 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
19365088 MGI
is active in cytosol IDA
IDA: Inferred from direct assay
26851500 MGI
located in nucleus IDA
IDA: Inferred from direct assay
19365088 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ketohexokinase

  • hepatic fructokinase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-17613 Evocalcet Activator 99.28% Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9925 Brodalumab Inhibitor 99.18% Unkown
HY-P9923 Benralizumab 99.46% Unkown

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-U00461 PF-06835919 Inhibitor 99.53% Phase 2
HY-149987 LY3522348 Inhibitor 98.30% Phase 1
Inhibitory Antibodies (5)
Cat. No. Product Name Effect
Purity Phase
HY-P99955 Rocatinlimab 99.95% Phase 3
HY-P990610 KHK-2898 Inhibitor 97.16% Phase 1
HY-P990609 KHK-2866 98.23% Phase 1
HY-P991282 KHK2823 Inhibitor / Phase 1
HY-P991536 KHK6640 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P9923A Benralizumab (anti-IL5RA) Inducer 99.60% Unkown
HY-12841A KHK-IN-1 hydrochloride Inhibitor 98.95% Unkown
HY-103478 KHK-IN-2 Inhibitor 99.05% Unkown
HY-12841 KHK-IN-1 Inhibitor 99.00% Unkown
HY-159123 KHK-6 Inhibitor / Unkown
HY-180921 GS-1291269 Inhibitor / Unkown
HY-RS07240 KHK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-149605 KHK-IN-4 Inhibitor / Unkown
HY-162982 KHK-IN-6 / Unkown
HY-163886 KHK-IN-5 Inhibitor / Unkown
HY-172610 KHK-IN-7 Inhibitor / Unkown
HY-17613S Evocalcet-d4 Activator / Unkown
HY-208737 KHK-IN-8 Inhibitor / Unkown
HY-RS17728 Khk Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24193 Khk Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991918 KHK2840 Agonist / Unkown
HY-P992004 KHK2805 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Khk NCBI NCBI:3795