DMP1 - dentin matrix acidic phosphoprotein 1 Gene

Also Known as ARHP; ARHR; DMP-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1758

About DMP1

Cytogenetic location: 4q22.1 Genomic coordinates (GRCh38): 4:87,650,280-87,664,357 (from NCBI)

This gene has 7 transcripts (splice variants), 109 orthologues and is associated with 3 phenotypes. Low expression observed in reference dataset.

Summary

Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small Integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

DMP1 Products (2)

mRNA	Protein	Name
NM_001079911.3	NP_001073380.1	dentin matrix acidic phosphoprotein 1 isoform 2 precursor
NM_004407.4	NP_004398.1	dentin matrix acidic phosphoprotein 1 isoform 1 precursor

DMP1 Protein Structure

DMP1

0
100
200
300
400
513 a.a.

Protein Preferred Names	Protein Names
dentin matrix acidic phosphoprotein 1	dentin matrix protein 1

Recombinant DMP1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70105	DMP-1 Protein, Human (HEK293, His)	Q13316 (L17-Y513)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Hypophosphatemic Rickets, Autosomal Recessive, 1	ARHR1 Arhp Hypophosphatemic Rickets, Ar Arhr Hypophosphatemia, Autosomal Recessive Hypophosphatemia Autosomal Recessive Autosomal Recessive Hypophosphatemic Vitamin D Refractory Rickets
Hypophosphatemic Rickets, X-Linked Recessive	Hypophosphatemic Rickets X-Linked Recessive Hypophosphatemic Rickets XLRHR Hypophosphatemic Rickets Disorders Rickets Hypophosphatemic Rickets, Hypophosphatemic, X-Linked Recessive Familial Hypophosphatemic Rickets
Autosomal Recessive Hypophosphatemic Rickets	Arhr Hypophosphatemic Rickets, Autosomal Recessive Autosomal Recessive Hypophosphatemic Vitamin D Refractory Rickets
Osteomalacia	Adult Rickets
Hypophosphatemia	Vitamin D-Resistant Rickets Hereditary Hypophosphatemic Rickets Vdrr Vitamin D Resistant Rickets Hypophosphatemic Rickets, X-Linked Dominant Familial Hypophosphatemic Rickets
Rickets	Vitamin D Deficiency Vitamin D Active Rickets Hypovitaminosis D Nutritional Rickets Vitamin D Deficiency Disease Vitamin-D Deficiency Rickets Vitamin D-Dependent Rickets Avitaminosis D Infantile Osteomalacia Juvenile Osteomalacia
Dentinogenesis Imperfecta	Hereditary Opalescent Dentin Dentinogenesis Imperfecta Without Osteogenesis Imperfecta Dgi Capdepont Teeth Dgi Without Oi Di Non-Syndromic Dgi Non-Syndromic Dentinogenesis Imperfecta Opalescent Teeth Without Oi Opalescent Teeth Without Osteogenesis Imperfecta Opalescent Dentin
Dentinogenesis Imperfecta 1	Capdepont Teeth Dentinogenesis Imperfecta Type 2 Opalescent Dentin Dentinogenesis Imperfecta Without Osteogenesis Imperfecta Dgi-Ii Dentinogenesis Imperfecta, Shields Type 2 DGI1 Opalescent Teeth Without Osteogenesis Imperfecta Dentinogenesis Imperfecta, Shields Type Ii Dgi-2 Di-2 DGI2 Dentinogenesis Imperfecta Shields Type Ii Non-Syndromic Dentinogenesis Imperfecta Non-Syndromic Dgi
Dentin Dysplasia	Dentinal Dysplasia Dd Dysplasia, Dentin Shell Teeth
Raine Syndrome	Lethal Osteosclerotic Bone Dysplasia RNS Renal Nutcracker Syndrome Osteomalacia, Sclerosing, With Cerebral Calcification Left Renal Vein Entrapment Syndrome Csocc Osteosclerotic Bone Dysplasia, Lethal Combination Of Microcephaly, Exophthalmos, Hypoplastic Nose And Midface, Gum Hyperplasia, Cleft Palate, Apparently Low-Set Ears, And Osteosclerosis Nutcracker Syndrome
Vitamin D-Dependent Rickets Type 2b
Nephrolithiasis/Osteoporosis, Hypophosphatemic, 1	Hypophosphatemic Nephrolithiasis/Osteoporosis 1 NPHLOP1 Nephrolithiasis-Osteoporosis, Hypophosphatemic, 1 Nephrolithiasis/Osteoporosis, Hypophosphatemic, Type 1
Root Resorption
Dental Pulp Necrosis	Pulp Necrosis Necrotic Pulp Necrosis Of The Pulp Dead Pulp Devitalised Pulp Putrescent Pulpitis Devitalized Tooth Dental Pulp Gangrene Pulp Gangrene Nonvital Tooth Pulpless Tooth Putrescent Pulp
Fanconi Renotubular Syndrome 2	FRTS2 Fanconi Renotubular Syndrome, Type 2
Hypophosphatemic Nephrolithiasis/Osteoporosis	Nephrolithiasis/Osteoporosis, Hypophosphatemic
Sclerosteosis 1	SOST1 Sost Cortical Hyperostosis With Syndactyly Sclerosteosis Sclerosteosis, Type 1
Osteoglophonic Dysplasia	Osteoglophonic Dwarfism OGD Fairbank-Keats Syndrome Osteoglosphonic Dysplasia Dysplasia, Osteoglophonic
Dental Caries	Dental Caries Extending Into Pulp Dental Caries Of Smooth Surface Dental Caries Pit And Fissure Smooth Surface Dental Caries Dental Decay Carious Teeth Dental Cavity Saprodontia Teeth Decayed Tooth Caries Tooth Decay
Dental Pulp Disease	Dental Pulp Diseases Dental Pulp Disorder Disorder Of Pulp Of Tooth Pulp Disorder
Hypophosphatemic Rickets, Autosomal Dominant	Autosomal Dominant Hypophosphatemic Rickets ADHR Autosomal Dominant Hypophosphatemia Vitamin D-Resistant Rickets, Autosomal Dominant Hypophosphatemia, Autosomal Dominant Autosomal Dominant Vitamin D-Resistant Rickets Rickets, Hypophosphatemic, Autosomal Dominant
Vitamin D Hydroxylation-Deficient Rickets, Type 1b	VDDR1B Vitamin D-Dependent Rickets Type 1b Vitamin D-Dependent Rickets, Type 1b 25-Hydroxyvitamin D3 Deficiency, Selective Pseudovitamin D3 Deficiency Rickets Due To 25-Hydroxylase Deficiency Rickets Due To Defect In Vitamin D 25-Hydroxylation Deficiency Rickets Vitamin D-Dependent 1b 25-Hydroxyvitamimn D3 Deficiency Selective 25-Hydroxyvitamin D(3) Deficiency Pseudovitamin D(3) Deficiency Rickets Due To 25-Hydroxylase Deficiency Selective 25-Hydroxyvitamin D(3) Deficiency Rickets Due To Defect In Vitamin D 25-Hydroxylation
Hypophosphatemic Rickets, X-Linked Dominant	X-Linked Hypophosphatemia Xlh Vitamin D-Resistant Rickets, X-Linked X-Linked Hypophosphatemic Rickets XLHR Hyp Hypophosphatemic Vitamin D-Resistant Rickets Hpdr X-Linked Dominant Hypophosphatemic Rickets Familial Hypophosphatemic Rickets Hypophosphatemia, X-Linked Hypophosphatemia, Vitamin D-Resistant Rickets Hypophosphatemic Rickets X-Linked Dominant X-Linked Vitamin D-Resistant Rickets Hypophophatemia, X-Linked Hypophophatemic Vitamin D-Resistant Rickets Hypophosphatemia X-Linked Vitamin D-Resistant Rickets X-Linked Vitamin D-Resistant Rickets Rickets, X-Linked Hypophosphatemic
Vitamin D Hydroxylation-Deficient Rickets, Type 1a	Vitamin D-Dependent Rickets, Type 1a Vitamin D-Dependent Rickets, Type 1 VDDR1A 25-Hydroxycholecalciferol-1-Hydroxylase Deficiency 1-Alpha-Hydroxylase Deficiency Vdd1 Pddr1a Pddr Ia Vitamin D-Dependent Rickets, Type I Vitamin D-Dependent Rickets Type 1a 1-Alpha, 25-Hydroxyvitamin D3 Deficiency, Selective Vitamin D Dependency, Type 1 Pseudovitamin D-Deficiency Rickets, Type Ia Rickets Vitamin D-Dependent 1a 1-Alpha 25-Hydroxyvitamin D3 Deficiency Selective Pddr Pseudovitamin D Deficiency Rickets Pseudovitamin D-Deficiency Rickets Type Ia Vitamin D Dependency Type 1
Familial Isolated Hypoparathyroidism	Fih
Arterial Calcification Of Infancy	Idiopathic Infantile Arterial Calcification Generalized Arterial Calcification Of Infancy Iiac Occlusive Infantile Arteriopathy Infantile Arteriosclerosis Gaci Idiopathic Obliterative Arteriopathy Generalized Arterial Calcification In Infancy Arteriopathia Calcificans Infantum Diffuse Arterial Calcifying Elastopathy Of Infancy Infantile Calcifying Arteriopathy Medial Coronary Sclerosis Of Infancy Coronary Sclerosis, Medial, Of Infancy Calcification, Arterial, Generalized, Infancy
Dental Abscess
Vitamin D-Dependent Rickets, Type 2a	Hvdrr Generalized Resistance To 1,25-Dihydroxyvitamin D Hypocalcemic Vitamin D-Resistant Rickets VDDR2A Rickets, Hereditary Vitamin D-Resistant Vitamin D-Resistant Rickets With End-Organ Unresponsiveness To 1,25-Dihydroxycholecalciferol Pddr Iia Rickets-Alopecia Syndrome Rickets, Vitamin D-Resistant, Type Iia Vitamin D-Dependent Rickets Type 2a Vitamin D-Dependent Rickets, Type 2 Vitamin D-Dependent Rickets, Type 2a, With Or Without Alopecia Generalized 1,25-Dihydroxyvitamin D Pseudovitamin D-Deficiency, Type Iia Hereditary Vitamin D-Resistant Rickets Vddr Ii Vdrr Ii Vitamin D-Dependent Rickets Type Ii Vitamin D-Resistant Rickets Type Ii Rickets Vitamin D-Dependent 2a Pseudovitamin D-Deficiency Type Iia Rickets Hereditary Vitamin D-Resistant Type Iia Rickets Vitamin D-Dependent Rickets Type 2a With Or Without Alopecia Vitamin D-Dependent Rickets, Type Ii Familial Hypophosphatemic Rickets Hypophosphatemic Rickets, X-Linked Dominant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03826	DMP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS03833	DMTF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19893	Dmp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26393	Dmp1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	DMP1	VGNC	VGNC:57414
Mus musculus	DMP1	MGD	MGI:94910
Rattus norvegicus	DMP1	RGD	RGD:2508
Felis catus	DMP1	VGNC	VGNC:107327
Macaca mulatta	DMP1	VGNC	VGNC:71933
Bos taurus	DMP1	VGNC	VGNC:28108
Others	DMP1	NCBI