1. Gene
  2. Ntrk1 - neurotrophic tyrosine kinase, receptor, type 1 Gene

Ntrk1 - neurotrophic tyrosine kinase, receptor, type 1 Gene

Mus musculus

Also known as Tkr; trk; TrkA

Gene ID: 18211 | Gene type: protein coding

About Ntrk1

Chromosome 3: 87,685,551-87,702,469 reverse strand.GRCm39:CM000996.3

This gene has 1 transcript (splice variant), 200 orthologues, 53 paralogues and is associated with 36 phenotypes. Biased expression in adrenal adult (RPKM 7.1), CNS E14 (RPKM 2.8) and 13 other tissues.

Summary

Predicted to enable several functions, including GPI-linked Ephrin Receptor activity; nerve growth factor binding activity; and nerve growth factor receptor activity. Involved in axonogenesis involved in innervation; negative regulation of neuron apoptotic process; and sympathetic nervous system development. Acts upstream of or within several processes, including behavioral response to formalin induced pain; nerve growth factor signaling pathway; and nervous system development. Located in axon; cell surface; and endosome. Is expressed in several structures, including branchial arch; gonad; nervous system; sensory organ; and urogenital ridge. Used to study hereditary sensory neuropathy. Human ortholog(s) of this gene implicated in Alzheimer's disease; hereditary sensory neuropathy; hereditary sensory neuropathy type 4; and schizophrenia. Orthologous to human NTRK1 (neurotrophic receptor tyrosine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Ntrk1 Products(1)

mRNA Protein Name
NM_001033124.1 NP_001028296.1 high affinity nerve growth factor receptor precursor

Ntrk1 Protein Structure

LRR_1

LRR_1: sd00031 (67 - 91)

LRR_8

LRR_8: pfam13855 (91 - 149)

LRR_1

LRR_1: sd00031 (92 - 115)

LRR_1

LRR_1: sd00031 (116 - 138)

LRR_1

LRR_1: sd00031 (139 - 151)

TPKR_C2

TPKR_C2: pfam16920 (150 - 193)

Ig

Ig: cl11960 (196 - 283)

Ig

Ig: cd00096 (212 - 216)

Ig

Ig: cd00096 (225 - 229)

Ig

Ig: cd00096 (248 - 252)

Ig

Ig: cd00096 (263 - 268)

Ig

Ig: cd00096 (276 - 279)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (286 - 292)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (286 - 381)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (294 - 297)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (300 - 308)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (311 - 318)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (321 - 324)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (329 - 335)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (343 - 351)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (359 - 367)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (370 - 378)

PKc_like

PKc_like: cl21453 (506 - 785)

  • 0
  • 200
  • 400
  • 600
  • 799 a.a.
Protein Preferred Names Protein Names

high affinity nerve growth factor receptor

Recombinant Ntrk1 Proteins

Cat. No. Product Name Accession Purity
HY-P72437 TrkA Protein, Mouse (385a.a, HEK293, His) Q3UFB7 (A34-P418) ≥95%
HY-P76115 TrkA Protein, Mouse (HEK293, Fc) Q3UFB7 (M1-G420) ≥95%
HY-P76116 TrkA Protein, Mouse (HEK293, His) Q3UFB7/NP_001028296.1 (A34-G420) ≥95%

Orthologs Information

Species Symbol Source ID
Homo sapiens Ntrk1 NCBI NCBI:4914
Canis familiaris Ntrk1 NCBI NCBI:490404
Leporidae Ntrk1 NCBI
Rattus norvegicus Ntrk1 NCBI NCBI:59109