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Ntrk1 - neurotrophic tyrosine kinase, receptor, type 1 Gene

Also Known as Tkr; trk; TrkA

Species: Mus musculus

Gene Type: protein coding

Gene ID: 18211

About Ntrk1

Chromosome 3: 87,685,551-87,702,469 reverse strand.GRCm39:CM000996.3

This gene has 1 transcript (splice variant), 200 orthologues, 53 paralogues and is associated with 36 phenotypes. Biased expression in adrenal adult (RPKM 7.1), CNS E14 (RPKM 2.8) and 13 other tissues.

Summary

Predicted to enable several functions, including GPI-linked Ephrin Receptor activity; nerve growth factor binding activity; and nerve growth factor receptor activity. Involved in axonogenesis involved in innervation; negative regulation of neuron apoptotic process; and sympathetic nervous system development. Acts upstream of or within several processes, including behavioral response to formalin induced pain; nerve growth factor signaling pathway; and nervous system development. Located in axon; cell surface; and endosome. Is expressed in several structures, including branchial arch; gonad; nervous system; sensory organ; and urogenital ridge. Used to study hereditary sensory neuropathy. Human ortholog(s) of this gene implicated in Alzheimer's disease; hereditary sensory neuropathy; hereditary sensory neuropathy type 4; and schizophrenia. Orthologous to human NTRK1 (neurotrophic receptor tyrosine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Ntrk1 Products (1)

mRNA	Protein	Name
NM_001033124.1	NP_001028296.1	high affinity nerve growth factor receptor precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16049186	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within B cell differentiation	IMP IMP: Inferred from mutant phenotype	15459109	MGI
involved in axonogenesis involved in innervation	IMP IMP: Inferred from mutant phenotype	8815902	MGI
acts upstream of or within behavioral response to formalin induced pain	IMP IMP: Inferred from mutant phenotype	24760869	MGI
acts upstream of or within cellular response to nerve growth factor stimulus	IDA IDA: Inferred from direct assay	24760869	MGI
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	23785138	MGI
acts upstream of or within innervation	IMP IMP: Inferred from mutant phenotype	24760869	MGI
acts upstream of or within mechanoreceptor differentiation	IMP IMP: Inferred from mutant phenotype	15376326	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IGI IGI: Inferred from genetic interaction	11731452	MGI
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	8815902	MGI
acts upstream of or within nerve growth factor signaling pathway	IDA IDA: Inferred from direct assay	7854358	MGI
acts upstream of or within nerve growth factor signaling pathway	IGI IGI: Inferred from genetic interaction	24270184	MGI
acts upstream of or within nervous system development	IDA IDA: Inferred from direct assay	12810599	MGI
acts upstream of neuron apoptotic process	IGI IGI: Inferred from genetic interaction	11731452	MGI
acts upstream of or within positive regulation of synapse assembly	IDA IDA: Inferred from direct assay	24613359	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	11877420	MGI
involved in sympathetic nervous system development	IMP IMP: Inferred from mutant phenotype	8815902	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in axon	IDA IDA: Inferred from direct assay	24270184	MGI
located in cell surface	IDA IDA: Inferred from direct assay	24760869	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	10207144	MGI
located in early endosome	IDA IDA: Inferred from direct assay	24270184	MGI
located in late endosome	IDA IDA: Inferred from direct assay	24760869	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	27076424	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ntrk1 Protein Structure

LRR_1

LRR_8

LRR_1

TPKR_C2

IgI_TrKABC_d5

PKc_like

0
200
400
600
799 a.a.

Protein Preferred Names	Protein Names
high affinity nerve growth factor receptor

Recombinant Ntrk1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76115	TrkA Protein, Mouse (HEK293, Fc)	Q3UFB7/NP_001028296.1 (A34-G420)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P76116	TrkA Protein, Mouse (HEK293, His)	Q3UFB7/NP_001028296.1 (A34-G420)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-131003	Taletrectinib	Inhibitor	99.63%	Unkown

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-131003A	Taletrectinib free base	Inhibitor	/	Unkown
HY-101977A	(R,S)-Selitrectinib	Inhibitor	/	Unkown
HY-144451	TRK-IN-12	Inhibitor	/	Unkown
HY-156086	TRK-IN-24	Inhibitor	/	Unkown
HY-180172	TRK-IN-33		/	Unkown
HY-181052	PROTAC NTRK1 degrader-1	Degrader	/	Unkown
HY-185545	NTRK1-ligand-1	Ligand	/	Unkown
HY-E70869	TRKA(NTRK1) Recombinant Human Active Protein Kinase		/	Unkown
HY-RS09628	NTRK1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09629	Ntrk1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09630	Ntrk1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-185546	CRBN ligand-900 Gly		/	Unkown
HY-D3447	LPd peroxida probe-2		99.17%	Unkown
HY-W1115186	CRBN ligand-900		/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990589	GBR-900		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ntrk1	NCBI	NCBI:4914