Mfn1 - mitofusin 1 Gene

Also Known as Fzo1b

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 192647

Summary

Enables identical protein binding activity. Involved in several processes, including cellular response to decreased oxygen levels; regulation of mitochondrion organization; and response to glucocorticoid. Located in mitochondrial inner membrane and mitochondrial outer membrane. Biomarker of several diseases, including adult respiratory distress syndrome; dental fluorosis; kidney failure (multiple); pulmonary hypertension; and status epilepticus. Orthologous to human MFN1 (mitofusin 1). [provided by Alliance of Genome Resources, Apr 2022]

Mfn1 Products (1)

mRNA Protein Name
NM_138976.2 NP_620432.2 mitofusin-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
14561718 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to dexamethasone stimulus IEP
IEP: Inferred from expression pattern
22703557 RGD
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
28518143 RGD
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
23658809 RGD
involved in intracellular distribution of mitochondria IMP
IMP: Inferred from mutant phenotype
19605646 RGD
involved in male gonad development IEP
IEP: Inferred from expression pattern
14592431 RGD
involved in mitochondrion organization IMP
IMP: Inferred from mutant phenotype
19605646 RGD
involved in negative regulation of mitochondrial fission IMP
IMP: Inferred from mutant phenotype
18832378 RGD
involved in positive regulation of dendritic spine morphogenesis IMP
IMP: Inferred from mutant phenotype
19605646 RGD
involved in positive regulation of mitochondrial fusion IMP
IMP: Inferred from mutant phenotype
24751540 RGD
involved in response to calcium ion IEP
IEP: Inferred from expression pattern
25308841 RGD
involved in response to corticosterone IEP
IEP: Inferred from expression pattern
22244747 RGD
involved in response to electrical stimulus IEP
IEP: Inferred from expression pattern
26513006 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
24751540 RGD
involved in response to flavonoid IEP
IEP: Inferred from expression pattern
24637344 RGD
involved in response to fluoride IEP
IEP: Inferred from expression pattern
24958380 RGD
involved in response to hypobaric hypoxia IEP
IEP: Inferred from expression pattern
24637344 RGD
involved in response to manganese ion IEP
IEP: Inferred from expression pattern
15589972 RGD
involved in response to muscle activity IEP
IEP: Inferred from expression pattern
19716857 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
25336449 RGD
Cellular Component GO Annotation Evidence References Source
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
27801955 RGD
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
27801955 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mitofusin-1

  • mitochondrial transmembrane GTPase FZO1B

  • transmembrane GTPase MFN1

Mfn1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P80751 Mitofusin 1 Antibody (YA291) WB, IP Mouse, Rat, Hamster
HY-P80751A Mitofusin 1 Antibody (YA291)(PBS only) WB, IP Mouse, Rat, Hamster

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-150031 MFI8 Inhibitor 99.67% Unkown
HY-126124 AP39 96.35% Unkown
HY-139109 IR-783 99.87% Unkown
HY-P3429A SAMβA TFA Inhibitor 99.13% Unkown
HY-P3429 SAMβA Inhibitor 99.14% Unkown
HY-RS08383 MFN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P5891 TAT-SAMβA Antagonist / Unkown
HY-RS17749 Mfn1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24215 Mfn1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mfn1 NCBI NCBI:55669