EFNA3 - ephrin A3 Gene

Also Known as EFL2; EPLG3; LERK3; Ehk1-L

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1944

About EFNA3

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:155,078,837-155,087,538 (from NCBI)

This gene has 3 transcripts (splice variants), 180 orthologues and 7 paralogues. Biased expression in skin (RPKM 20.5), esophagus (RPKM 8.1) and 3 other tissues.

Summary

This gene encodes a member of the ephrin (EPH) family. The Ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, Ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. [provided by RefSeq, Jul 2008]

EFNA3 Products (1)

mRNA Protein Name
NM_004952.5 NP_004943.1 ephrin-A3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables ephrin receptor binding IPI
IPI: Inferred from physical interaction
11519828 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in ephrin receptor signaling pathway IGI
IGI: Inferred from genetic interaction
24217950 GOA
involved in negative regulation of angiogenesis IDA
IDA: Inferred from direct assay
18417479 GOA
involved in positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process IGI
IGI: Inferred from genetic interaction
24217950 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EFNA3 Protein Structure

Ephrin

Ephrin: Ephrin (29 - 170)

  • 0
  • 100
  • 200
  • 238 a.a.
Protein Preferred Names Protein Names

ephrin-A3

  • EFL-2

EFNA3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EFNA3 P52797 KRTAP1-1 Homo sapiens Q07627
Validated Y2H
32296183
Intra
EFNA3 P52797 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra
EFNA3 P52797 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra
EFNA3 P52797 LCE2C Homo sapiens Q5TA81
Y2H Array
32296183
Intra
EFNA3 P52797 LCE2C Homo sapiens Q5TA81
Y2H Prey Pooling
32296183
Intra
EFNA3 P52797 LCE2C Homo sapiens Q5TA81
Validated Y2H
32296183
Intra
EFNA3 P52797 MEOX2 Homo sapiens P50222
Validated Y2H
25416956
Intra
EFNA3 P52797 MEOX2 Homo sapiens P50222
Y2H Prey Pooling
25416956
Intra
EFNA3 P52797 NOTCH2NLA Homo sapiens Q7Z3S9
Validated Y2H
25416956
Intra
EFNA3 P52797 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
25416956
Intra
EFNA3 P52797 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EFNA3 Proteins

Cat. No. Product Name Accession Purity
HY-P70375 Ephrin-A3/EFNA3 Protein, Human (HEK293, His) P52797-1 (Q23-S211) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73007 Ephrin-A3/EFNA3 Protein, Human (HEK293, Fc) P52797-1 (Q23-S213) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04194 EFNA3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17546 Efna3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24005 Efna3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus EFNA3 RGD RGD:620390
Mus musculus EFNA3 MGD MGI:106644
Others EFNA3 NCBI