Tacr3 - tachykinin receptor 3 Gene

Also Known as Nkr; Nmkr; Tac3r

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24808

About Tacr3

Primary_assembly 2: 223,266,536-223,363,791 forward strand.mRatBN7.2:CM026975.1

This gene has 1 transcript (splice variant), 258 orthologues, 50 paralogues and is associated with 14 phenotypes. Biased expression in Brain (RPKM 3.9), Kidney (RPKM 7.7) and 4 other tissues.

Summary

Enables tachykinin receptor activity. Involved in several processes, including hyperosmotic salinity response; positive regulation of uterine smooth muscle contraction; and response to alkaloid. Located in several cellular components, including dendrite membrane; neuronal cell body membrane; and nucleus. Used to study hypertension. Biomarker of visual epilepsy. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 11 with or without anosmia. Orthologous to human TACR3 (tachykinin receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

Tacr3 Products (1)

mRNA Protein Name
NM_017053.1 NP_058749.1 neuromedin-K receptor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables tachykinin receptor activity IDA
IDA: Inferred from direct assay
1662278 RGD
Biological Process GO Annotation Evidence References Source
involved in positive regulation of blood pressure IDA
IDA: Inferred from direct assay
2478257 RGD
involved in positive regulation of heart rate IDA
IDA: Inferred from direct assay
2471579 RGD
involved in positive regulation of uterine smooth muscle contraction IDA
IDA: Inferred from direct assay
12390879 RGD
involved in regulation of dopamine metabolic process IDA
IDA: Inferred from direct assay
8574643 RGD
involved in regulation of feeding behavior IDA
IDA: Inferred from direct assay
2462199 RGD
involved in response to cocaine IMP
IMP: Inferred from mutant phenotype
17445241 RGD
involved in response to estradiol IDA
IDA: Inferred from direct assay
12390879 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
10342838 RGD
Cellular Component GO Annotation Evidence References Source
located in dendrite membrane IDA
IDA: Inferred from direct assay
16357093 RGD
located in neuronal cell body membrane IDA
IDA: Inferred from direct assay
16357093 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tacr3 Protein Structure

7tmA_NKR_NK3R

7tmA_NKR_NK3R: cd16003 (72 - 353)

7tmA_NKR_NK3R

7tmA_NKR_NK3R: cd16003 (73 - 99)

7tmA_NKR_NK3R

7tmA_NKR_NK3R: cd16003 (106 - 132)

7tmA_NKR_NK3R

7tmA_NKR_NK3R: cd16003 (144 - 174)

7tmA_NKR_NK3R

7tmA_NKR_NK3R: cd16003 (185 - 206)

7tmA_NKR_NK3R

7tmA_NKR_NK3R: cd16003 (230 - 259)

7tmA_NKR_NK3R

7tmA_NKR_NK3R: cd16003 (278 - 308)

7tmA_NKR_NK3R

7tmA_NKR_NK3R: cd16003 (321 - 346)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 452 a.a.
Protein Preferred Names Protein Names

neuromedin-K receptor

  • NK-3 receptor

  • NK-3R

  • Neuromedin K receptor (Neurokinin B/Tachikin 3)

  • neurokinin B receptor

  • tachikin receptor 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14149 TACR3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14150 Tacr3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14151 Tacr3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tacr3 NCBI NCBI:6870