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Tbxa2r - thromboxane A2 receptor Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 24816

About Tbxa2r

Primary_assembly 7: 8,383,378-8,388,176 reverse strand.mRatBN7.2:CM026980.1

This gene has 1 transcript (splice variant), 193 orthologues, 8 paralogues and is associated with 22 phenotypes. Biased expression in Thymus (RPKM 14.9), Lung (RPKM 32.5) and 7 other tissues.

Summary

Enables thromboxane receptor activity. Involved in several processes, including cellular response to lipopolysaccharide; positive regulation of vasoconstriction; and response to testosterone. Located in acrosomal vesicle and plasma membrane. Used to study adult respiratory distress syndrome; kidney failure; thrombocytopenia; and toxic shock syndrome. Human ortholog(s) of this gene implicated in aspirin-induced respiratory disease; asthma; and blood platelet disease. Orthologous to human TBXA2R (thromboxane A2 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Tbxa2r Products (1)

mRNA	Protein	Name
NM_017054.2	NP_058750.2	thromboxane A2 receptor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20959415	RGD
enables thromboxane receptor activity	IDA IDA: Inferred from direct assay	7635958	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	10513923	RGD
involved in positive regulation of angiogenesis	IDA IDA: Inferred from direct assay	16720756	RGD
involved in positive regulation of blood coagulation	IMP IMP: Inferred from mutant phenotype	7848332	RGD
involved in positive regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	16115588	RGD
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	7635958	RGD
involved in positive regulation of vasoconstriction	IMP IMP: Inferred from mutant phenotype	10513923	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	9262373	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	14621185	RGD
involved in response to testosterone	IEP IEP: Inferred from expression pattern	8092292	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	11409645	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in acrosomal vesicle	IDA IDA: Inferred from direct assay	7649122	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tbxa2r Protein Structure

7tm_GPCRs

0
100
200
300
341 a.a.

Protein Preferred Names	Protein Names
thromboxane A2 receptor	TXA2-R TXR2 Thromboxane receptor prostanoid TP receptor

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-106891	Domitroban	Antagonist	/	Unkown
HY-RS14283	TBXA2R Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14284	Tbxa2r Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14285	Tbxa2r Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tbxa2r	NCBI	NCBI:6915