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Fmr1 - fragile X messenger ribonucleoprotein 1 Gene

Also Known as FMRP

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 24948

Summary

Enables several functions, including RNA binding activity; enzyme binding activity; and translation regulator activity. Involved in several processes, including modulation of chemical synaptic transmission; negative regulation of transport; and regulation of cellular protein metabolic process. Located in several cellular components, including cytoplasmic ribonucleoprotein granule; dendrite; and distal axon. Part of polysome. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic cytosol. Used to study autism spectrum disorder and fragile X syndrome. Biomarker of childhood onset epileptic encephalopathy; transient cerebral ischemia; and withdrawal disorder. Human ortholog(s) of this gene implicated in fragile X syndrome; fragile X-associated tremor/ataxia syndrome; and primary ovarian insufficiency 1. Orthologous to human FMR1 (FMRP translational regulator 1). [provided by Alliance of Genome Resources, Apr 2022]

Fmr1 Products (1)

mRNA	Protein	Name
NM_052804.2	NP_434691.1	fragile X messenger ribonucleoprotein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA 7-methylguanosine cap binding	IDA IDA: Inferred from direct assay	25453757	RGD
enables RNA binding	IDA IDA: Inferred from direct assay	12417734	RGD
enables mRNA binding	IPI IPI: Inferred from physical interaction	24338128	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	24882364	RGD
enables protein domain specific binding	IDA IDA: Inferred from direct assay	24882364	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	23831253	RGD
enables protein phosphatase binding	IDA IDA: Inferred from direct assay	23831253	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to L-glutamate	IEP IEP: Inferred from expression pattern	22817682	RGD
involved in cellular response to potassium ion	IEP IEP: Inferred from expression pattern	15028757	RGD
involved in detection of mechanical stimulus involved in sensory perception	IEP IEP: Inferred from expression pattern	12591163	RGD
involved in evoked excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	36536454	RGD
involved in glutamate receptor signaling pathway	IDA IDA: Inferred from direct assay	9144248	RGD
involved in intracellular glutamate homeostasis	IMP IMP: Inferred from mutant phenotype	38378836	RGD
involved in locomotory exploration behavior	IMP IMP: Inferred from mutant phenotype	36536454	RGD
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	24338128	RGD
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	22817682	RGD
involved in negative regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	24338128	RGD
involved in negative regulation of protein processing	IMP IMP: Inferred from mutant phenotype	22817682	RGD
involved in negative regulation of receptor internalization	IMP IMP: Inferred from mutant phenotype	17881561	RGD
involved in negative regulation of synaptic vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	24709664	RGD
involved in negative regulation of voltage-gated calcium channel activity	IMP IMP: Inferred from mutant phenotype	24709664	RGD
involved in ovarian follicle development	IEP IEP: Inferred from expression pattern	23401597	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	22817682	RGD
involved in positive regulation of long-term neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	28894415	RGD
involved in positive regulation of long-term synaptic depression	IMP IMP: Inferred from mutant phenotype	28894415	RGD
involved in positive regulation of long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	28894415	RGD
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	22817682	RGD
involved in positive regulation of synaptic transmission	IMP IMP: Inferred from mutant phenotype	28894415	RGD
involved in regulation of neuronal action potential	IMP IMP: Inferred from mutant phenotype	27465362	RGD
involved in regulation of neurotransmitter secretion	IMP IMP: Inferred from mutant phenotype	24709664	RGD
involved in regulation of translation at presynapse, modulating synaptic transmission	IDA IDA: Inferred from direct assay	24709664	RGD
involved in regulation of translation at presynapse, modulating synaptic transmission	IMP IMP: Inferred from mutant phenotype	24709664	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	11001622	RGD
involved in response to cocaine	IEP IEP: Inferred from expression pattern	24810662	RGD
involved in response to electrical stimulus	IEP IEP: Inferred from expression pattern	10686356	RGD
involved in response to gonadotropin	IEP IEP: Inferred from expression pattern	23401597	RGD
involved in response to interleukin-1	IEP IEP: Inferred from expression pattern	10587350	RGD
involved in response to light stimulus	IEP IEP: Inferred from expression pattern	15564573	RGD

Cellular Component GO Annotation	Evidence	References	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	9144248	RGD
located in axon	IDA IDA: Inferred from direct assay	16809002	RGD
located in axon terminus	IDA IDA: Inferred from direct assay	9030614	RGD
located in cell body	IDA IDA: Inferred from direct assay	17881655	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	14613971	RGD
located in cytoplasmic ribonucleoprotein granule	IDA IDA: Inferred from direct assay	16098134	RGD
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	16510718	RGD
located in dendrite	IDA IDA: Inferred from direct assay	9030614	RGD
located in dendritic filopodium	IDA IDA: Inferred from direct assay	15028757	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	9030614	RGD
located in dendritic spine head	IDA IDA: Inferred from direct assay	15028757	RGD
located in dendritic spine neck	IDA IDA: Inferred from direct assay	15028757	RGD
located in glial cell projection	IDA IDA: Inferred from direct assay	14613971	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	9144248	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	24709664	RGD
located in growth cone	IDA IDA: Inferred from direct assay	16098134	RGD
located in microtubule cytoskeleton	IDA IDA: Inferred from direct assay	17881655	RGD
located in neuron projection	IDA IDA: Inferred from direct assay	24709664	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	15028757	RGD
located in neuronal ribonucleoprotein granule	IDA IDA: Inferred from direct assay	17881655	RGD
located in nucleoplasm	IDA IDA: Inferred from direct assay	9030614	RGD
located in nucleus	IDA IDA: Inferred from direct assay	9030614	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	9030614	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	23831253	RGD
is active in postsynaptic cytosol	IDA IDA: Inferred from direct assay	9144248	RGD
located in postsynaptic density	IDA IDA: Inferred from direct assay	9144248	RGD
located in proximal dendrite	IDA IDA: Inferred from direct assay	12112448	RGD
located in spine apparatus	IDA IDA: Inferred from direct assay	9030614	RGD
located in terminal bouton	IDA IDA: Inferred from direct assay	15028757	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
fragile X messenger ribonucleoprotein 1 synaptic functional regulator FMR1	FMRP translational regulator 1 protein FMR-1

Protein Preferred Names

Protein Names

fragile X messenger ribonucleoprotein 1

synaptic functional regulator FMR1

FMRP translational regulator 1
protein FMR-1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100786	DL-AP3		≥98.0%	Unkown
HY-160887	FPT	Agonist	98.06%	Unkown
HY-181828	SePP	Antagonist	/	Unkown
HY-RS05011	FMR1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05012	FMR1NB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-185723	rG4 WT_AHPC_PEG2		99.80%	Unkown
HY-RS19332	Fmr1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25823	Fmr1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fmr1	NCBI	NCBI:2332