2. Membrane Transporter/Ion Channel Neuronal Signaling GPCR/G Protein
  3. iGluR Dopamine Receptor
  4. SePP

SePP is a blood-brain barrier-permeable NMDAR antagonist and dopamine/norepinephrine reuptake inhibitor, with a Ki of 28.7 nM for rat NMDAR. SePP exerts anticonvulsant effects. SePP can be used in research related to fragile X syndrome.

For research use only. We do not sell to patients.

SePP

SePP Chemical Structure

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SePP Related Antibodies

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Description

SePP is a blood-brain barrier-permeable NMDAR antagonist and dopamine/norepinephrine reuptake inhibitor, with a Ki of 28.7 nM for rat NMDAR. SePP exerts anticonvulsant effects. SePP can be used in research related to fragile X syndrome[1].

IC50 & Target[1]

NMDA Receptor

28.7 nM (Ki)

In Vitro

SePP (multiple concentrations; 2 h) potently binds to rat forebrain NMDARs with a Ki of 28.7 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SePP Related Antibodies
Parmacokinetics
Species Dose Route Plasma Concentration
Mice[1] 10 mg/kg i.p. 387.5 ng/mL
In Vivo

SePP (10 mg/kg; i.p.) completely suppresses audiogenic seizures in juvenile Fmr1 knockout mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: FVB.129P2-Pde6b+ Tyrc‑ch Fmr1tm1Cgr/J (Fmr1 knockout, 4 male and 4 female, postnatal day 23-25, audiogenic seizure induction)[1]
Dosage: 10 mg/kg
Administration: i.p.; single dose
Result: Abolished wild running and jumping (WRJ), tonic-clonic seizure (TCS), and respiratory arrest (RA) in all treated mice, with statistically significant differences compared to vehicle controls (P < 0.0001 for WRJ and TCS, P = 0.0013 for RA).
Exhibited normal behaviors including exploring, rearing, grooming, and interacting with cage-mates during testing.
Molecular Weight

318.32

Formula

C17H21NSe
SMILES

C1(CC(N2CCCCC2)C3=CC=C[Se]3)=CC=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SePP Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SePPiGluRDopamine ReceptorIonotropic glutamate receptorsdopamine/norepinephrine reuptake inhibitorphencyclidine siteNMDARDATblood-brain barrier permeabilityfragile X syndromeNETrat forebrain NMDARsFmr1 knockout micehuman SERTInhibitorinhibitorinhibit

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