Chrna5 - cholinergic receptor nicotinic alpha 5 subunit Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25102

Summary

Enables acetylcholine binding activity and acetylcholine-gated cation-selective channel activity. Predicted to be involved in several processes, including behavioral response to nicotine; cholinergic synaptic transmission; and regulation of synaptic vesicle exocytosis. Located in dendrite; neuronal cell body; and plasma membrane. Part of acetylcholine-gated channel complex. Human ortholog(s) of this gene implicated in lung Cancer. Orthologous to human CHRNA5 (cholinergic receptor nicotinic alpha 5 subunit). [provided by Alliance of Genome Resources, Apr 2022]

Chrna5 Products (1)

mRNA Protein Name
NM_017078.2 NP_058774.2 neuronal acetylcholine receptor subunit alpha-5 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables acetylcholine binding IDA
IDA: Inferred from direct assay
11297818 RGD
enables acetylcholine-gated monoatomic cation-selective channel activity IMP
IMP: Inferred from mutant phenotype
11297818 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
20566638 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
20796176 RGD
Biological Process GO Annotation Evidence References Source
involved in behavioral response to nicotine IMP
IMP: Inferred from mutant phenotype
21278726 RGD
involved in cellular response to nicotine IMP
IMP: Inferred from mutant phenotype
30293722 RGD
involved in detection of mechanical stimulus involved in sensory perception of pain IMP
IMP: Inferred from mutant phenotype
15652389 RGD
involved in hippocampus development IEP
IEP: Inferred from expression pattern
15558717 RGD
involved in regulation of neuronal action potential IMP
IMP: Inferred from mutant phenotype
30293722 RGD
Cellular Component GO Annotation Evidence References Source
part of acetylcholine-gated channel complex IDA
IDA: Inferred from direct assay
20796176 RGD
located in dendrite IDA
IDA: Inferred from direct assay
11297818 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
11297818 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neuronal acetylcholine receptor subunit alpha-5

  • acetylcholine receptor alpha 5

  • cholinergic receptor, nicotinic, alpha 5 (neuronal)

  • cholinergic receptor, nicotinic, alpha polypeptide 5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS19054 Chrna5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02670 CHRNA5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25544 Chrna5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Chrna5 NCBI NCBI:1138