Dpysl3 - dihydropyrimidinase-like 3 Gene

Also Known as Crmp4; TUC-4b

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25418

Summary

Enables SH3 domain binding activity; chondroitin sulfate binding activity; and identical protein binding activity. Involved in several processes, including actin filament organization; regulation of plasma membrane bounded cell projection organization; and response to axon injury. Located in several cellular components, including cell body; growth cone; and lamellipodium. Part of filamentous actin. Is active in synapse. Colocalizes with exocytic vesicle. Orthologous to human DPYSL3 (dihydropyrimidinase like 3). [provided by Alliance of Genome Resources, Apr 2022]

Dpysl3 Products (2)

mRNA Protein Name
NM_001398556.1 NP_001385485.1 dihydropyrimidinase-related protein 3 isoform 2
NM_012934.2 NP_037066.1 dihydropyrimidinase-related protein 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables SH3 domain binding IDA
IDA: Inferred from direct assay
12684468 RGD
enables chondroitin sulfate binding IDA
IDA: Inferred from direct assay
12444086 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
16181627 RGD
Biological Process GO Annotation Evidence References Source
involved in actin crosslink formation IDA
IDA: Inferred from direct assay
16181627 RGD
involved in actin filament bundle assembly IDA
IDA: Inferred from direct assay
16181627 RGD
involved in cellular response to cytokine stimulus IEP
IEP: Inferred from expression pattern
20800647 RGD
involved in negative regulation of cell migration IMP
IMP: Inferred from mutant phenotype
16181627 RGD
involved in negative regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
17301178 RGD
involved in neuron development IEP
IEP: Inferred from expression pattern
8815901 RGD
involved in positive regulation of filopodium assembly IDA
IDA: Inferred from direct assay
17301178 RGD
involved in positive regulation of neuron projection development IDA
IDA: Inferred from direct assay
12684468 RGD
involved in response to axon injury IEP
IEP: Inferred from expression pattern
20800647 RGD
Cellular Component GO Annotation Evidence References Source
located in cell body IDA
IDA: Inferred from direct assay
16181627 RGD
located in cytosol IDA
IDA: Inferred from direct assay
16181627 RGD
located in exocytic vesicle IDA
IDA: Inferred from direct assay
12684468 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
12444086 RGD
part of filamentous actin IDA
IDA: Inferred from direct assay
16181627 RGD
located in growth cone IDA
IDA: Inferred from direct assay
12684468 RGD
located in lamellipodium IDA
IDA: Inferred from direct assay
16181627 RGD
is active in synapse EXP
EXP: Inferred from Experiment
15169875 RGD
is active in synapse IDA
IDA: Inferred from direct assay
15169875 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dihydropyrimidinase-related protein 3

  • CRMP-4

  • DRP-3

  • TOAD-64/Ulip/CRMP protein 4b

  • collapsin response mediator protein 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03982 DPYSL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20151 Dpysl3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26655 Dpysl3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dpysl3 NCBI NCBI:1809