Hcrtr2 - hypocretin receptor 2 Gene

Also Known as ox2r; ox2-R; ox-2-R

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25605

About Hcrtr2

Primary_assembly 8: 76,989,834-77,105,893 reverse strand.mRatBN7.2:CM026981.1

This gene has 1 transcript (splice variant), 199 orthologues, 16 paralogues and is associated with 2 phenotypes. Restricted expression toward (RPKM 92.5).

Summary

Enables orexin receptor activity and peptide hormone binding activity. Involved in feeding behavior and neuropeptide signaling pathway. Predicted to be integral component of plasma membrane. Biomarker of hyperglycemia. Orthologous to human HCRTR2 (hypocretin receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Hcrtr2 Products (2)

mRNA Protein Name
NM_013074.2 NP_037206.1 orexin receptor type 2 isoform 1
NM_001393819.1 NP_001380748.1 orexin receptor type 2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled receptor activity IDA
IDA: Inferred from direct assay
9491897 RGD
enables orexin receptor activity IDA
IDA: Inferred from direct assay
9491897 RGD
enables peptide hormone binding IDA
IDA: Inferred from direct assay
12890892 RGD
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
12890892 RGD
involved in feeding behavior IDA
IDA: Inferred from direct assay
9491897 RGD
involved in neuropeptide signaling pathway IDA
IDA: Inferred from direct assay
9491897 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hcrtr2 Protein Structure

7tmA_OXR

7tmA_OXR: cd15208 (54 - 374)

7tmA_OXR

7tmA_OXR: cd15208 (55 - 81)

7tmA_OXR

7tmA_OXR: cd15208 (88 - 114)

7tmA_OXR

7tmA_OXR: cd15208 (126 - 156)

7tmA_OXR

7tmA_OXR: cd15208 (167 - 188)

7tmA_OXR

7tmA_OXR: cd15208 (219 - 248)

7tmA_OXR

7tmA_OXR: cd15208 (296 - 326)

7tmA_OXR

7tmA_OXR: cd15208 (342 - 367)

Orexin_rec2

Orexin_rec2: pfam03827 (385 - 442)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 460 a.a.
Protein Preferred Names Protein Names

orexin receptor type 2

  • hypocretin (orexin) receptor 2

  • hypocretin receptor type 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06054 HCRTR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02206 CD200R1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06055 Hcrtr2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06056 Hcrtr2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hcrtr2 NCBI NCBI:3062