HCRTR2 - hypocretin receptor 2 Gene

Also Known as OX2R; OXR2; ORXR2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3062

About HCRTR2

Cytogenetic location: 6p12.1 Genomic coordinates (GRCh38): 6:55,106,469-55,284,713 (from NCBI)

This gene has 2 transcripts (splice variants), 199 orthologues and 16 paralogues. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A. [provided by RefSeq, Jan 2009]

HCRTR2 Products (3)

mRNA Protein Name
NM_001526.5 NP_001517.2 orexin receptor type 2
NM_001384272.1 NP_001371201.1 orexin receptor type 2
XM_017010798.2 XP_016866287.1 orexin receptor type 2 isoform X1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables orexin receptor activity IDA
IDA: Inferred from direct assay
26950369 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
Biological Process GO Annotation Evidence References Source
involved in neuropeptide signaling pathway IDA
IDA: Inferred from direct assay
26950369 GOA
involved in regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
26950369 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
26950369 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HCRTR2 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (71 - 364)

Orexin_rec2

Orexin_rec2: Orexin receptor type 2 (384 - 444)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 444 a.a.
Protein Preferred Names Protein Names

orexin receptor type 2

  • hypocretin (orexin) receptor 2

  • hypocretin receptor type 2

  • orexin type-2 receptor

Related Diseases

Diseases Alias
Periodic Limb Movement Disorder

  • Nocturnal Myoclonus Syndrome

  • Nocturnal Myoclonus
Headache

  • Headache Disorder
Cluster Headache

  • Headache, Cluster
Von Economo'S Disease

  • Encephalitis Lethargica

  • Von Economo Encephalitis

  • Von Economo Disease
Migraine With Or Without Aura 1

  • Migraine

  • Migraine With Or Without Aura, Susceptibility To, 1

  • Migraine Disorder

  • Migraine Variant

  • Migraines

  • Migraine Disorders

  • Mgr1

  • Mgau

  • Ma

  • Migraine With Or Without Aura

  • Classic Migraine

  • Common Migraine

  • Disorder, Migraine

  • Headache Migraine

  • Headache Migrainous

  • Migraine Headache

  • Migraine Syndrome

  • Headache Including Migraine

  • Migraine, Susceptibility To
Major Depressive Disorder

  • Seasonal Affective Disorder

  • Unipolar Depression

  • Depression

  • MDD

  • Depressive Disorder

  • Unipolar Depression, Susceptibility To

  • Major Depressive Disorder 1

  • Major Depressive Disorder, Response To Citalopram Therapy In

  • Major Depressive Disorder 2

  • Winter Depression

  • Single Major Depressive Episode

  • Sad

  • Clinical Depression

  • Major Depression

  • Depressive Syndrome

  • Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment

  • Seasonal Affective Disorder, Susceptibility To

  • Recurrent Major Depression

  • Affective Disorder, Seasonal

  • Depression In A Seasonal Pattern

  • Depression

  • Seasonal

  • Major Depressive Disorder With A Seasonal Pattern

  • Seasonal Depression

  • Seasonal Mood Disorder

  • Mental Depression

  • Recurrent Major Depressive Episodes
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Obesity , Susceptibility To

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Narcolepsy

  • Paroxysmal Sleep

  • Gelineau Syndrome

  • Narcoleptic Syndrome

  • Narcolepsy-Cataplexy Syndrome

  • Cataplexy And Narcolepsy

  • Narcolepsy, Without Cataplexy

  • Gelineau'S Syndrome

  • Narcolepsy With Or Without Cataplexy

  • Narcolepsy Nos
Advanced Sleep Phase Syndrome

  • Fasps

  • Familial Advanced Sleep-Phase Syndrome

  • Advanced Sleep Phase Syndrome, Familial

  • Familial Advanced Sleep Phase Syndrome

  • Sleep Phase Syndrome, Advanced, Familial

  • Advanced Sleep-Phase Syndrome, Familial
Recurrent Hypersomnia

  • Primary Recurrent Hypersomnia

  • Hypersomnia Recurrent

  • Disorders Of Excessive Somnolence

  • Hypersomnia, Recurrent
Sleep Disorder

  • Sleep Disorders

  • Non-Organic Sleep Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06054 HCRTR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02206 CD200R1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06055 Hcrtr2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06056 Hcrtr2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta HCRTR2 VGNC VGNC:73357
Bos taurus HCRTR2 VGNC VGNC:29782
Mus musculus HCRTR2 MGD MGI:2680765
Felis catus HCRTR2 VGNC VGNC:67545
Canis familiaris HCRTR2 VGNC VGNC:41624
Rattus norvegicus HCRTR2 RGD RGD:2788
Others HCRTR2 NCBI