Fkbp1a - FKBP prolyl isomerase 1A Gene

Also Known as Fkbp2; FKBP12

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25639

Summary

Enables several functions, including FK506 binding activity; HSP70 protein binding activity; and type I transforming growth factor beta receptor binding activity. Involved in response to iron ion. Located in axon terminus and intracellular membrane-bounded organelle. Biomarker of Parkinsonism. Orthologous to several human genes including FKBP1A (FKBP prolyl isomerase 1A). [provided by Alliance of Genome Resources, Apr 2022]

Fkbp1a Products (1)

mRNA Protein Name
NM_013102.3 NP_037234.2 peptidyl-prolyl cis-trans isomerase FKBP1A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables FK506 binding IDA
IDA: Inferred from direct assay
9013543 RGD
enables Hsp70 protein binding IPI
IPI: Inferred from physical interaction
17877381 RGD
enables enzyme binding IPI
IPI: Inferred from physical interaction
17877381 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
17877381 RGD
enables transforming growth factor beta receptor binding IDA
IDA: Inferred from direct assay
7518616 RGD
enables type I transforming growth factor beta receptor binding IDA
IDA: Inferred from direct assay
7518616 RGD
Biological Process GO Annotation Evidence References Source
involved in response to iron ion IEP
IEP: Inferred from expression pattern
17546681 RGD
Cellular Component GO Annotation Evidence References Source
located in axon terminus IDA
IDA: Inferred from direct assay
12494287 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

peptidyl-prolyl cis-trans isomerase FKBP1A

  • 12 kDa FK506-binding protein

  • 12 kDa FKBP

  • FK506 binding protein 1a

  • FK506 binding protein 2 (13 kDa)

  • FK506-binding protein 1 (12kD)

  • FK506-binding protein 1A

  • FKBP-12

  • FKBP-1A

  • PPIase FKBP1A

  • immunophilin FKBP12

  • rotamase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04960 FKBP1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18309 Fkbp1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24787 Fkbp1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fkbp1a NCBI NCBI:2280