Tnfrsf12a - tumor necrosis factor receptor superfamily, member 12a Gene

Also Known as Fn14; HPIP; TweakR; TWEAK-R

Species: Mus musculus

Gene Type: protein coding
Gene ID: 27279

Summary

Involved in regulation of angiogenesis. Acts upstream of or within extrinsic apoptotic signaling pathway; positive regulation of axon extension; and substrate-dependent cell migration, cell attachment to substrate. Located in cell surface; plasma membrane; and ruffle. Is expressed in several structures, including adrenal medulla; genitourinary system; heart; limb long bone; and molar. Orthologous to human TNFRSF12A (TNF Receptor Superfamily member 12A). [provided by Alliance of Genome Resources, Apr 2022]

Tnfrsf12a Products (2)

mRNA Protein Name
NM_001161746.1 NP_001155218.1 tumor necrosis factor receptor superfamily member 12A isoform 2 precursor
NM_013749.2 NP_038777.2 tumor necrosis factor receptor superfamily member 12A isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14573547 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell adhesion IDA
IDA: Inferred from direct assay
10551889 MGI
acts upstream of or within extrinsic apoptotic signaling pathway IDA
IDA: Inferred from direct assay
12821115 MGI
acts upstream of or within positive regulation of axon extension IDA
IDA: Inferred from direct assay
14573547 MGI
involved in regulation of angiogenesis IDA
IDA: Inferred from direct assay
11728344 MGI
acts upstream of or within substrate-dependent cell migration, cell attachment to substrate IDA
IDA: Inferred from direct assay
10551889 MGI
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
12821115 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
10551889 MGI
located in ruffle IDA
IDA: Inferred from direct assay
14573547 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tumor necrosis factor receptor superfamily member 12A

  • FGF-inducible 14

  • fibroblast growth factor-inducible immediate-early response protein 14

  • fibroblast growth factor-regulated protein 2

  • tweak-receptor

  • type I transmembrane protein Fn14

Recombinant Tnfrsf12a Proteins

Cat. No. Product Name Accession Purity
HY-P72435 TNFRSF12A Protein, Mouse (HEK293, Fc) Q9CR75 (E28-W79) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700229AF Animal-Free TWEAK/TNFSF12 Protein, Mouse (His) O54907 (S94-H249) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P991439 BIIB023 Inhibitor / Phase 2
HY-P99361 Enavatuzumab Inhibitor 98.27% Phase 1

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14803 TNFRSF12A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17480 Tnfrsf12a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23938 Tnfrsf12a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991433 BIIB036 Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tnfrsf12a NCBI NCBI:51330