GMPR - guanosine monophosphate reductase Gene

Also Known as GMPR1; GMPR 1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2766

About GMPR

Cytogenetic location: 6p22.3 Genomic coordinates (GRCh38): 6:16,238,587-16,295,549 (from NCBI)

This gene has 4 transcripts (splice variants), 208 orthologues and 3 paralogues. Broad expression in prostate (RPKM 33.0), testis (RPKM 29.5) and 19 other tissues.

Summary

This gene encodes an enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of GMP to IMP. The protein also functions in the re-utilization of free intracellular Bases and purine nucleosides.[provided by RefSeq, Oct 2009]

GMPR Products (1)

mRNA Protein Name
NM_006877.4 NP_006868.3 GMP reductase 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables GMP reductase activity IDA
IDA: Inferred from direct assay
22332716 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
33961781 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GMPR Protein Structure

IMPDH

IMPDH: IMP dehydrogenase / GMP reductase domain (9 - 341)

  • 0
  • 100
  • 200
  • 300
  • 345 a.a.
Protein Preferred Names Protein Names

GMP reductase 1

  • guanine monophosphate reductase

GMPR Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
GMPR P36959 GMPR2 Homo sapiens Q9P2T1
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GMPR Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P70955 GMPR Protein, Human (HEK293, His) AAH08281.1 (M1-S345) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75791 GMPR Protein, Human (His) P36959/NP_006868.3 (M1-S345) ≥ 85%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Viral Gastritis
Cystathioninuria

  • Cystathionase Deficiency

  • Gamma-Cystathionase Deficiency

  • Cystathione Gamma-Lyase Deficiency Syndrome

  • Cystathionine Gamma-Lyase Deficiency Syndrome

  • CSTNU
Fumarase Deficiency

  • Fumaric Aciduria

  • FMRD

  • Fumarate Hydratase Deficiency

  • Deficiency, Fumarase
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS05527 GMPR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05526 GMPR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19137 Gmpr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22531 Gmpr2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25627 Gmpr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29051 Gmpr2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GMPR MGD MGI:1913605
Macaca mulatta GMPR VGNC VGNC:73082
Rattus norvegicus GMPR RGD RGD:70980
Felis catus GMPR VGNC VGNC:62612
Canis familiaris GMPR VGNC VGNC:41294
Bos taurus GMPR VGNC VGNC:29442
Others GMPR NCBI