GMPR2 - guanosine monophosphate reductase 2 Gene

Also Known as GMPR 2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51292

About GMPR2

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:24,232,622-24,239,242 (from NCBI)

This gene has 29 transcripts (splice variants), 1 gene allele, 187 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 24.5), kidney (RPKM 21.7) and 25 other tissues.

Summary

This gene encodes an enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of guanosine monophosphate (GMP) to inosine monophosphate (IMP). The protein also functions in the re-utilization of free intracellular Bases and purine nucleosides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]

GMPR2 Products (12)

mRNA Protein Name
NM_001002000.3 NP_001002000.1 GMP reductase 2 isoform 2
NM_001002001.3 NP_001002001.1 GMP reductase 2 isoform 2
NM_001002002.3 NP_001002002.1 GMP reductase 2 isoform 2
NM_001283021.2 NP_001269950.1 GMP reductase 2 isoform 3
NM_001283022.2 NP_001269951.1 GMP reductase 2 isoform 4
NM_001283023.2 NP_001269952.1 GMP reductase 2 isoform 5
NM_001351022.2 NP_001337951.1 GMP reductase 2 isoform 6
NM_001351023.2 NP_001337952.1 GMP reductase 2 isoform 6
NM_001351024.2 NP_001337953.1 GMP reductase 2 isoform 7
NM_001351025.2 NP_001337954.1 GMP reductase 2 isoform 7
NM_001351026.2 NP_001337955.1 GMP reductase 2 isoform 7
NM_016576.5 NP_057660.2 GMP reductase 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables GMP reductase activity IDA
IDA: Inferred from direct assay
12669231 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in GMP metabolic process IDA
IDA: Inferred from direct assay
22037469 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GMPR2 Protein Structure

IMPDH

IMPDH: IMP dehydrogenase / GMP reductase domain (9 - 341)

  • 0
  • 100
  • 200
  • 300
  • 348 a.a.
Protein Preferred Names Protein Names

GMP reductase 2

  • guanosine 5'-monophosphate oxidoreductase 2

GMPR2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GMPR2 Q9P2T1 GMPR Homo sapiens P36959
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Urethra Cancer

  • Cancer Of Urethra

  • Malignant Tumour Of Urethra

  • Malignant Urethral Neoplasm

  • Urethral Ca
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05527 GMPR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22531 Gmpr2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29051 Gmpr2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris GMPR2 VGNC VGNC:41295
Mus musculus GMPR2 MGD MGI:1917903
Macaca mulatta GMPR2 VGNC VGNC:73083
Felis catus GMPR2 VGNC VGNC:62613
Rattus norvegicus GMPR2 RGD RGD:628875
Others GMPR2 NCBI