2. Gene
  3. GMPR2 - guanosine monophosphate reductase 2 Gene

GMPR2 - guanosine monophosphate reductase 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GMPR 2

Gene ID: 51292 | Gene type: protein coding

About GMPR2

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:24,232,622-24,239,242 (from NCBI)

This gene has 29 transcripts (splice variants), 1 gene allele, 187 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 24.5), kidney (RPKM 21.7) and 25 other tissues.

Summary

This gene encodes an Enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of guanosine monophosphate (GMP) to inosine monophosphate (IMP). The protein also functions in the re-utilization of free intracellular bases and purine nucleosides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]

GMPR2 Products(12)

mRNA Protein Name
NM_001002000.3 NP_001002000.1 GMP reductase 2 isoform 2
NM_001002001.3 NP_001002001.1 GMP reductase 2 isoform 2
NM_001002002.3 NP_001002002.1 GMP reductase 2 isoform 2
NM_001283021.2 NP_001269950.1 GMP reductase 2 isoform 3
NM_001283022.2 NP_001269951.1 GMP reductase 2 isoform 4
NM_001283023.2 NP_001269952.1 GMP reductase 2 isoform 5
NM_001351022.2 NP_001337951.1 GMP reductase 2 isoform 6
NM_001351023.2 NP_001337952.1 GMP reductase 2 isoform 6
NM_001351024.2 NP_001337953.1 GMP reductase 2 isoform 7
NM_001351025.2 NP_001337954.1 GMP reductase 2 isoform 7
NM_001351026.2 NP_001337955.1 GMP reductase 2 isoform 7
NM_016576.5 NP_057660.2 GMP reductase 2 isoform 1

GMPR2 Protein Structure

IMPDH

IMPDH: IMP dehydrogenase / GMP reductase domain (9 - 341)

  • 0
  • 100
  • 200
  • 300
  • 348 a.a.
Protein Preferred Names Protein Names

GMP reductase 2

guanosine 5'-monophosphate oxidoreductase 2

Related Diseases

Diseases Alias
Urethra Cancer

Cancer Of Urethra

Malignant Tumour Of Urethra

Malignant Urethral Neoplasm

Urethral Ca
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05527 GMPR2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris GMPR2 VGNC VGNC:41295
Mus musculus GMPR2 MGD MGI:1917903
Macaca mulatta GMPR2 VGNC VGNC:73083
Felis catus GMPR2 VGNC VGNC:62613
Rattus norvegicus GMPR2 RGD RGD:628875