GNG11 - G protein subunit gamma 11 Gene

Also Known as HG3H1; GNGT11

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2791

About GNG11

Cytogenetic location: 7q21.3 Genomic coordinates (GRCh38): 7:93,921,735-93,928,610 (from NCBI)

This gene has 1 transcript (splice variant), 169 orthologues and 11 paralogues. Broad expression in fat (RPKM 168.6), placenta (RPKM 159.2) and 18 other tissues.

Summary

This gene is a member of the guanine nucleotide-binding protein (G protein) gamma family and encodes a lipid-anchored, cell membrane protein. As a member of the heterotrimeric G protein complex, this protein plays a role in this transmembrane signaling system. This protein is also subject to carboxyl-terminal processing. Decreased expression of this gene is associated with splenic marginal zone lymphomas. [provided by RefSeq, Jul 2008]

GNG11 Products (1)

mRNA Protein Name
NM_004126.4 NP_004117.1 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GNG11 Protein Structure

G-gamma

G-gamma: GGL domain (11 - 72)

  • 0
  • 73 a.a.
Protein Preferred Names Protein Names

guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11

  • G protein gamma-11 subunit

GNG11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GNG11 P61952 REP15 Homo sapiens Q6BDI9
Y2H Array
32296183
Intra
GNG11 P61952 REP15 Homo sapiens Q6BDI9
Validated Y2H
32296183
Intra
GNG11 P61952 REP15 Homo sapiens Q6BDI9
Y2H Prey Pooling
32296183
Intra
GNG11 P61952 CEP44 Homo sapiens Q9C0F1
Validated Y2H
32296183
Intra
GNG11 P61952 CEP44 Homo sapiens Q9C0F1
Y2H Array
32296183
Intra
GNG11 P61952 CEP44 Homo sapiens Q9C0F1
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05553 GNG11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22534 Gng11 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29054 Gng11 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris GNG11 VGNC VGNC:41317
Mus musculus GNG11 MGD MGI:1913316
Felis catus GNG11 VGNC VGNC:80053
Rattus norvegicus GNG11 RGD RGD:621515
Macaca mulatta GNG11 VGNC VGNC:81319
Bos taurus GNG11 VGNC VGNC:53646
Others GNG11 NCBI