Il27ra - interleukin 27 receptor subunit alpha Gene

Predicted to enable cytokine binding activity and interleukin-27 receptor activity. Predicted to contribute to interleukin-12 receptor binding activity and interleukin-23 binding activity. Predicted to be involved in several processes, including negative regulation of T-helper 17 type immune response; negative regulation of cytokine production; and positive regulation of activated T cell proliferation. Predicted to act upstream of or within several processes, including defense response to Gram-positive bacterium; positive regulation of interferon-gamma production; and regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. Predicted to be part of interleukin-12 receptor complex and interleukin-23 receptor complex. Predicted to be active in external side of plasma membrane. Orthologous to human IL27RA (interleukin 27 receptor subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]