Fdx1 - ferredoxin 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29189

Summary

Enables electron transfer activity; enzyme binding activity; and iron ion binding activity. Contributes to NADPH-adrenodoxin reductase activity and Cholesterol monooxygenase (side-chain-cleaving) activity. Involved in several processes, including NADPH oxidation; cellular response to epinephrine stimulus; and cellular response to Leptin stimulus. Located in mitochondrial crista and mitochondrial matrix. Biomarker of pancreatitis. Orthologous to human FDX1 (ferredoxin 1). [provided by Alliance of Genome Resources, Apr 2022]

Fdx1 Products (1)

mRNA Protein Name
NM_017126.2 NP_058822.2 adrenodoxin, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to NADPH-adrenodoxin reductase activity IDA
IDA: Inferred from direct assay
8789462 RGD
contributes to cholesterol monooxygenase (side-chain-cleaving) activity IDA
IDA: Inferred from direct assay
8789462 RGD
enables electron transfer activity IDA
IDA: Inferred from direct assay
8789462 RGD
enables enzyme binding IPI
IPI: Inferred from physical interaction
10525147 RGD
enables iron ion binding IDA
IDA: Inferred from direct assay
8789462 RGD
Biological Process GO Annotation Evidence References Source
involved in NADPH oxidation IDA
IDA: Inferred from direct assay
10525147 RGD
involved in adrenal gland development IEP
IEP: Inferred from expression pattern
8097866 RGD
involved in cellular response to epinephrine stimulus IEP
IEP: Inferred from expression pattern
11064152 RGD
involved in cellular response to leptin stimulus IEP
IEP: Inferred from expression pattern
10098510 RGD
involved in cellular response to organic cyclic compound IEP
IEP: Inferred from expression pattern
11064152 RGD
involved in positive regulation of oxidoreductase activity IMP
IMP: Inferred from mutant phenotype
11325963 RGD
involved in regulation of catalytic activity IDA
IDA: Inferred from direct assay
8789462 RGD
involved in response to gonadotropin IEP
IEP: Inferred from expression pattern
16139340 RGD
involved in response to leptin IEP
IEP: Inferred from expression pattern
11604238 RGD
Cellular Component GO Annotation Evidence References Source
located in mitochondrial crista IDA
IDA: Inferred from direct assay
16139340 RGD
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
2170421 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

adrenodoxin, mitochondrial

  • adrenal ferredoxin

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-12040 Elesclomol 99.43% Phase 3

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04854 FDX1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16591 Fdx1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-178914 Copper ionophore I 99.9% Unkown
HY-RS16223 Fdx1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-12040S Elesclomol-d2 / Unkown
HY-182919 Antitumor photosensitizer-10 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fdx1 NCBI NCBI:2230