MYL11 - myosin light chain 11 Gene

Also Known as DA1C; MLC2B; MRLC2; MYLPF; HUMMLC2B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 29895

About MYL11

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:30,370,934-30,377,991 (from NCBI)

This gene has 5 transcripts (splice variants), 251 orthologues, 7 paralogues and is associated with 3 phenotypes. Biased expression in prostate (RPKM 32.5) and esophagus (RPKM 15.3).

Summary

Predicted to be a structural constituent of muscle. Predicted to be involved in skeletal muscle tissue development. Located in lysosomal membrane. Implicated in distal arthrogryposis type 1C. [provided by Alliance of Genome Resources, Apr 2022]

MYL11 Products (3)

mRNA Protein Name
NM_001324458.2 NP_001311387.1 myosin regulatory light chain 11
NM_001324459.2 NP_001311388.1 myosin regulatory light chain 11
NM_013292.5 NP_037424.2 myosin regulatory light chain 11

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
Biological Process GO Annotation Evidence References Source
involved in muscle contraction IMP
IMP: Inferred from mutant phenotype
32707087 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYL11 Protein Structure

EF-hand_6

EF-hand_6: EF-hand domain (29 - 55)

  • 0
  • 100
  • 169 a.a.
Protein Preferred Names Protein Names

myosin regulatory light chain 11

  • fast skeletal myosin light chain 2

MYL11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MYL11 Q96A32 JPH3 Homo sapiens Q8WXH2
Y2H Pooling
32814053
Intra
MYL11 Q96A32 JPH3 Homo sapiens Q8WXH2
Validated Y2H
32814053
Intra
MYL11 Q96A32 JPH3 Homo sapiens Q8WXH2
Y2H Array
32814053
Intra
MYL11 Q96A32 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
MYL11 Q96A32 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
MYL11 Q96A32 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
MYL11 Q96A32 GFAP Homo sapiens P14136
Y2H Array
32814053
Intra
MYL11 Q96A32 GFAP Homo sapiens P14136
Validated Y2H
32814053
Intra
MYL11 Q96A32 GFAP Homo sapiens P14136
Y2H Pooling
32814053
Intra
MYL11 Q96A32 PEX1 Homo sapiens O43933
Validated Y2H
32814053
Intra
MYL11 Q96A32 PEX1 Homo sapiens O43933
Y2H Array
32814053
Intra
MYL11 Q96A32 PEX1 Homo sapiens O43933
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

MYL11 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810704 MYL11/MYLPF Antibody WB, IHC-P, IHC-F, IF-Tissue Human, Mouse, Rat

Related Diseases

Diseases Alias
Arthrogryposis, Distal, Type 1c

  • DA1C

  • Distal Arthrogryposis Type 1c

  • Arthrogryposis, Distal, 1c
Distal Arthrogryposis

  • Arthrogryposis Multiplex Congenita

  • Arthrogryposis

  • Congenital Multiple Arthrogryposis

  • Congenital Arthromyodysplasia

  • Fibrous Ankylosis Of Multiple Joints

  • Guerin-Stern Syndrome

  • Guérin-Stern Syndrome

  • Myodystrophia Fetalis Deformans

  • Otto Syndrome

  • Rocher-Sheldon Syndrome

  • Rossi Syndrome

  • Amc

  • Multiple Congenital Arthrogryposis

  • Arthrogryposis Syndrome

  • Arthrogryposis, Distal

  • Distal Arthrogryposis Syndrome

  • Freeman-Sheldon Syndrome

  • Arthrogryposis, Distal, Type 2b

  • Congenital Multiplex Arthrogryposis

  • Amyoplasia Congenita

  • Congenital Amyoplasia

  • Amc - [Arthrogryposis Multiplex Congenita]
Congenital Contractures

  • Congenital Contracture
Scoliosis
Cardiomyopathy, Familial Hypertrophic, 1

  • Asymmetric Septal Hypertrophy

  • Familial Hypertrophic Cardiomyopathy

  • Hypertrophic Cardiomyopathy 1

  • CMH1

  • Hypertrophic Cardiomyopathy 19

  • CMH

  • Ventricular Hypertrophy, Hereditary

  • Ash

  • Hypertrophic Subaortic Stenosis, Idiopathic

  • Cardiomyopathy, Familial Hypertrophic

  • Cardiomyopathy, Hypertrophic, 1, Digenic

  • Cardiomyopathy, Familial Hypertrophic 1

  • Hcm

  • Hereditary Ventricular Hypertrophy

  • Idiopathic Hypertrophic Subaortic Stenosis

  • Hypertrophic Cardiomyopathy

  • Cardiomyopathy, Hypertrophic, Familial

  • Cardiomyopathy, Hypertrophic, 1

  • Familial Asymmetric Septal Hypertrophy

  • Heritable Hypertrophic Cardiomyopathy

  • Fhc

  • Cardiomyopathy, Hypertrophic, Familial, Type 1
Hypertrophic Cardiomyopathy

  • Hypertrophic Obstructive Cardiomyopathy

  • Cardiomyopathy, Hypertrophic

  • Cardiomyopathy Hypertrophic Obstructive

  • Cardiomyopathy, Hypertrophic, Familial

  • Idiopathic Myocardial Hypertrophy

  • Idiopathic Hypertrophic Cardiomyopathy

  • Obstructive Idiopathic Hypertrophic Cardiomyopathy

  • Obstructive Cardiomyopathy

  • Idiopathic Hypertrophic Subaortic Stenosis

  • Muscular Subaortic Stenosis

  • Hypertrophic Obstructive Subaortic Stenosis
Dilated Cardiomyopathy

  • Familial Dilated Cardiomyopathy

  • Primary Dilated Cardiomyopathy

  • Idiopathic Dilated Cardiomyopathy

  • Congestive Cardiomyopathy

  • Idiopathic Dilation Cardiomyopathy

  • Primary Familial Dilated Cardiomyopathy

  • Cardiomyopathy, Dilated

  • DCM

  • Cardiomyopathy, Familial Dilated

  • Dilated Cardiomyopathy, Familial

  • Hypokinetic Dilated Cardiomyopathy, Familial

  • Familial Idiopathic Cardiomyopathy

  • Fdc

  • Cardiomyopathy, Familial Idiopathic

  • Idiopathic Cardiomegaly

  • Dilated Congestive Cardiomyopathy

  • Chronic Dilated Cardiomyopathy

  • Ccm - [Congestive Cardiomyopathy]

  • Cocm - [Congestive Cardiomyopathy]

  • Dcm - [Dilated Cardiomyopathy]

  • Dilated-Hypokinetic Cardiomyopathy

  • Congestive Idiopathic Cardiomyopathy

  • Primary Idiopathic Dilated Cardiomyopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08911 MYL11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus MYL11 VGNC VGNC:31809
Macaca mulatta MYL11 VGNC VGNC:75044
Canis familiaris MYL11 VGNC VGNC:43552
Felis catus MYL11 VGNC VGNC:63683
Mus musculus MYL11 MGD MGI:97273
Rattus norvegicus MYL11 RGD RGD:3141
Others MYL11 NCBI