Serpinc1 - serpin family C member 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 304917

Summary

Enables heparin binding activity and serine-type endopeptidase inhibitor activity. Involved in acute inflammatory response to antigenic stimulus; lactation; and response to nutrient. Located in extracellular space. Used to study thrombosis. Biomarker of familial hyperlipidemia; nephrotic syndrome; and ovarian Cancer. Human ortholog(s) of this gene implicated in Antithrombin III deficiency; disseminated intravascular coagulation; intermediate coronary syndrome; thrombosis; and toxic shock syndrome. Orthologous to human SERPINC1 (Serpin family C member 1). [provided by Alliance of Genome Resources, Apr 2022]

Serpinc1 Products (1)

mRNA Protein Name
NM_001012027.1 NP_001012027.1 antithrombin-III precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables heparin binding IDA
IDA: Inferred from direct assay
7362830 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
7362830 RGD
enables serine-type endopeptidase inhibitor activity IDA
IDA: Inferred from direct assay
7362830 RGD
Biological Process GO Annotation Evidence References Source
involved in acute inflammatory response to antigenic stimulus IEP
IEP: Inferred from expression pattern
17850787 RGD
involved in lactation IEP
IEP: Inferred from expression pattern
22776112 RGD
involved in response to nutrient IDA
IDA: Inferred from direct assay
17123684 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
7930519 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

antithrombin-III

  • antithrombin III

  • serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1

  • serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1

  • serpin peptidase inhibitor, clade C (antithrombin), member 1

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-132587 Fitusiran 94.74% Unkown
HY-132587A Fitusiran sodium 95.08% Unkown
HY-132587C Fitusiran sodium scrambled negative control Activator / Unkown
HY-132587D FAM labled Fitusiran sodium / Unkown
HY-132587E Cy3 labled Fitusiran sodium / Unkown

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12718 SERPINC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18212 Serpinc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24689 Serpinc1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Serpinc1 NCBI NCBI:462