Rc3h2 - ring finger and CCCH-type zinc finger domains 2 Gene

Also Known as Mnab; Rnf164; 2900024N03Rik; 9430019J22Rik; D930043C02Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 319817

Summary

Enables mRNA binding activity. Involved in T cell receptor signaling pathway; negative regulation of T-helper 17 cell differentiation; and regulation of miRNA metabolic process. Acts upstream of or within several processes, including hematopoietic or lymphoid organ development; lymphocyte homeostasis; and positive regulation of NIK/NF-kappaB signaling. Predicted to be located in cell surface; intracellular membrane-bounded organelle; and membrane. Predicted to be active in cytoplasmic stress granule. Orthologous to human RC3H2 (ring finger and CCCH-type domains 2). [provided by Alliance of Genome Resources, Apr 2022]

Rc3h2 Products (2)

mRNA Protein Name
NM_001100591.1 NP_001094061.1 roquin-2 isoform a
NM_001290642.1 NP_001277571.1 roquin-2 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables mRNA binding IDA
IDA: Inferred from direct assay
23583643 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
23583643 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within B cell homeostasis IGI
IGI: Inferred from genetic interaction
23583643 MGI
acts upstream of or within T cell homeostasis IGI
IGI: Inferred from genetic interaction
23583643 MGI
acts upstream of or within T cell proliferation IGI
IGI: Inferred from genetic interaction
23583643 MGI
involved in T cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
25282160 MGI
acts upstream of or within T follicular helper cell differentiation IGI
IGI: Inferred from genetic interaction
23583643 MGI
acts upstream of or within limb development IMP
IMP: Inferred from mutant phenotype
23583643 MGI
acts upstream of or within lung alveolus development IMP
IMP: Inferred from mutant phenotype
23583643 MGI
acts upstream of or within lymph node development IGI
IGI: Inferred from genetic interaction
23583643 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
23583643 MGI
involved in negative regulation of T-helper 17 cell differentiation IMP
IMP: Inferred from mutant phenotype
25282160 MGI
acts upstream of or within positive regulation of non-canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
23583643 MGI
acts upstream of or within post-embryonic development IMP
IMP: Inferred from mutant phenotype
23583643 MGI
acts upstream of or within post-transcriptional regulation of gene expression IDA
IDA: Inferred from direct assay
23583643 MGI
acts upstream of or within regulation of gene expression IDA
IDA: Inferred from direct assay
23583643 MGI
involved in regulation of miRNA metabolic process IMP
IMP: Inferred from mutant phenotype
25697406 MGI
acts upstream of or within spleen development IGI
IGI: Inferred from genetic interaction
23583643 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

roquin-2

  • RING-type E3 ubiquitin transferase Roquin-2

  • membrane associated DNA binding protein

  • membrane-associated nucleic acid binding protein

  • ring finger and CCCH-type zinc finger domain-containing protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11778 RC3H2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21727 Rc3h2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28244 Rc3h2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rc3h2 NCBI NCBI:54542